retrotransposon ascertainment bias for the foreseeable future. This highlights the importance of developing analytical methods to overcome genome scarcity, which will in turn, allow researchers to confidently infer phylogenies from retrotransposon markers. Figure 1 Hypothetical example illustrating the “blind”...
When that is the case, the patients with sASD are not necessarily selected on the basis of parental bias in consultation favouring their children of one or the other sex, nor on the basis of strategic treatment-driven selection of a diagnosis. Rather, the search is often for a specific ...
In an example for continuous sibship data, these formulas show that estimates derived from conditioning on proband value have greater asymptotic bias than two other estimators. Similarly, either conditioning on proband value or conditioning on the number of affected family members resulted in biases ...
When autosomal and X-linked dominant inheritance mechanisms are known, as for example with retinitis pigmentosa, then only families where male-to-male transmission is observed may be readily counseled. The other pedigrees may be autosomal but lack male-to-male transmission due to chance segregation...
Fisher (1934) studied the bias in segregation frequency derived through incomplete as- certainment, and devised a formula for the estimation of ~r, consequently correcting the bias in segregation frequency. Introducing a concept of proportion of sporadic cases, Morton (I959) has developed ...
compared to controls with a FRAX® ≥ 15%, the screening group showed a significant reduction in major osteoporotic fractures (aHR 0.87, 95% CI 0.77–0.99) and hip fractures (aHR 0.74, 95% CI 0.58–0.95) was observed [21]. However, we note that a self-selection bias may be present ...
ascertainment biasgenerating functionsheterogeneityriskAnalysis of the bias of ascertainment is reformulated to deal with more general patterns commonly encountered in practice. The goal is to provide a unifying theory that will both replace the traditional, rather piecemeal, treatment of the problem and ...
We also implement the method proposed for a simple example and show that it allows us to reduce the bias substantially. AVAILABILITY: Further details and a computer program implementing the method are available from http://folk.uio.no/gillesg/AscB/.doi:10.1093/bioinformatics/btn665...
For example, an eligibility criterion for a family might be that both the mother and daughter have disease. Adjustments must be made for ascertainment to avoid bias. We propose adjusting for complex ascertainment schemes through a joint model for the outcomes of disease and ascertainment. This ...
ascertainment biasgenerating functionsheterogeneityriskAnalysis of the bias of ascertainment is reformulated to deal with more general patterns commonly encountered in practice. The goal is to provide a unifying theory that will both replace the traditional, rather piecemeal, treatment of the problem and ...