Bayesian correction for SNP ascertainment bias - Abad-Grau, Sebastiani - 2006 () Citation Context ...lable from the IHP website). The Supplementary Material contains also maps that were built using the ML estimates of r 2 , as well as the novel Bayesian estimator of D 0 that is ...
In addition to being more robust to violations of the in study assumptions, SNP data can be easier to collect since it does not require rare ins and thus also heritabipty for rare traits can be estimated ( with due correction for ascertainment bias ).Most individuals with tics...
Counseling for dominant traits: a correction for the ascertainment bias due to referral for analysis 来自 掌桥科研 喜欢 0 阅读量: 19 作者:K Gladstien,M. Anne Spence 摘要: Genetic heterogeneity complicates genetic counseling because the correct mode of inheritance must be determined independently for...
Chapter 1.2 addresses the evaluation of the ascertainment bias determined by the SNP discovery methods in the Bovine Hapmap experiment. It was confirmed ... L. P. Neto - Tjalling C. Koopmans Research Institute 被引量: 0发表: 2011年 Variance‐components QTL linkage analysis of selected and non...
Fisher (1934) studied the bias in segregation frequency derived through incomplete as- certainment, and devised a formula for the estimation of ~r, consequently correcting the bias in segregation frequency. Introducing a concept of proportion of sporadic cases, Morton (I959) has developed ...
Correction for this bias requires detailed knowledge of the array design process which is often not available in practice. This study intends to investigate an alternative approach to mitigate ascertainment bias of a large set of genotyped individuals by using information of a small set of sequenced...
For the first time, we demonstrate that ascertainment bias has an impact on the precision of morphological clock estimates. While analyses including molecular data suggested most divergences between placental orders occurred near the K銖刧 boundary, the partitioned morphological clock recovered older ...
We provide the first analysis of the impact of data partitioning and accounting for ascertainment bias on divergence time estimates employing the morphological clock. Both treatments of data reduce the uncertainty associated with estimates of node ages.Caldas, Ian V....
In this paper we propose a two‐stage method for ascertainment bias correction. In the first stage we estimate parameters that pertain to the ascertained population, that is the population that would be selected into the sample if the ascertainment criterion were applied to everyone. In the ...
Olson JM, Cordell HJ. Ascertainment bias in the estimation of sibling genetic risk parameters. Genet Epidemiol 2000; 18: 217±35.Olson JM,Cordell HJ.Ascertainment bias in the estimation of sibling genetic risk parameters.Genetic Epidemiology. 2000...