NKX2-1 appears to have additional, specific activity in regulating some cell-cycle genes independent of ASCL1 and PROX1. In addition, in contrast to the enrichment for the DepMap-defined common essential genes in the SE-associated gene lists, the genes directly regulated by ASCL1 and its co...
Data are representative of two independent experiments. Supplementary Figure 5 Model for T cell intrinsic ASC function during CNS inflammation. Supplementary Figure 6 The EAE phenotype of Cd3e−/−Il1b−/− chimera mice. (a) Lethal irradiated WT mice were reconstituted with WT+Cd3e-/- ...
However, this would be unlikely to change the final conclusion of this study that SA was not an independent risk factor of PAD, because of the insignificantly slightly decreased the risk of PAD in SA patients shown in the current study (hazard ratios of ≤0.9). Nevertheless, this posits the...