ASC基因是由MASUMOTO和CONWAY在分别研究白血病和乳腺癌时分离鉴定的一个新的与凋亡有关的抑癌基因,ASC基因属于CED4/Apafl基因家族,定位于人的16号染色体1区1带2亚带～1区2带之间,此蛋白分子包含195个氨基酸残基,它的N末端含有热蛋白样结构域(PYD);而从C末端开始的将近一半区域则被称为胱天蛋白酶募集域(CARD)...
TMS1/ASC基因,CARD,PYRIN,TMS1/ASC甲基化,肿瘤细胞凋亡相关的斑点样蛋白(ASC)由PYRIN(PYD)和CARD组成,是可逆的衔接分子.DNA甲 基化是一种可遗传性修饰,它有利于调节基因组的完整性并保证适当的基因表达.ASC在某些肿瘤中被甲基化而沉默,并表现生长抑制活性.本文对 TMS1/ASC甲基化后表达沉默与癌之间的关系做一...
50.asc蛋白,也称为pycard,是由pycard基因编码的衔接蛋白。它具有n末端pyrin结构域、c膜端半胱天冬酶募集结构域(card)和它们之间的接头区。asc蛋白在经由card-card相互作用的半胱天冬酶原-1和经由pyrin-pyrin相互作用的核苷酸结合寡聚结构域样受体(nlr)蛋白之间形成桥。 51.胞质溶胶中的nlr蛋白家族感知病原体相关...
pUNO1-hPYCARDa pUNO1 bearing the human PYCARD (ASC) gene, isoform 1 (long) Add to favorite 20 µg puno1-hpycarda ￥6,360 Please contact our distributor pUNO1-hPYCARD-DN pUNO1 bearing a dominant negative version of the human PYCARD (ASC) gene Add to favorite 20 µg ...
蛋白名全称 Apoptosis-associated speck-like protein containing a CARD 推荐稀释比 Western blot (WB) 1:500～2000Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400Flow Cytometry(Intracellular) 1～3μg/1×106 cellsDirect ELISA 1:100～1000 Gene ID 66824相关搜索:ASC/TMS1/PYCARD抗体,ASC抗体,TMS...
蛋白别名为:PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1;基因ID为:29108;蛋白质ID:Q9ULZ3 ...
5.验证细胞系:通过测序确认ASC/CARD5基因是否被成功敲除,并进行功能实验验证基因敲除的效果。 6. 扩大培养:筛选出ASC/CARD5基因敲除细胞系后,进行细胞系的扩大培养,为后续的细胞学和分子生物学实验做准备。 ASC/CARD5基因的基本信息 Species Gene Symbol Gene ID GenBank Accession Transcript Human (Homo sapiens...
1.Objective: Apoptosis associated speck—like protein containing CARD (ASC), also named target of methylation-induced silencing (TMS1), is an antioncogene, containing a pyrin(PYD) and a caspase recruitment domain (CARD), which play an important role in regulating apoptosis and immunological reactio...
该ASC / TMS1 Polyclonal Antibody. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle ...
like protein containing a CARD (ASC), whereas Z-VAD-fmk, a pan-caspase inhibitor, blocked the cell death after the oligomerization. Silencing of the ASC gene (Pycard) by small hairpin RNA treatment inhibited the NLRP3 mutant-induced cell death, but silencing of the caspase-1 gene (Casp1)...