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The presence of the FOXA2 motif suggests that FOXA2 might form a DNA-protein complex with ASCL1, PROX1, and/or NKX2-1; however, FOXA2 did not co-immunoprecipitate with these TFs in lysates from NCI-H2107 cells (data not shown). Overall the de novo motif analysis is consistent with ...
Full size image Cryo-EM structures of inward-open ASCT2 We determined the structure of the 172-kDa trimeric ASCT2C467R in presence of TBOA at 3.6 Å resolution by single particle cryo-EM (Fig. 2, Supplementary Figs. 1 and 4, Table 1). The protein was embedded in n-dodecyl-β-d...
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The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of the proinflammatory cytokine IL-1β (Zhao et al., 2020). IL-1β increases the expression of adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-...
Loans may have various features, terms, or covenant requirements. Debt balances need to reflect the full picture of an organization’s financial commitments at a point in time, so this is done in various ways depending on the form of debt. ...
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(a) only applies when a material retrospective change has occurred, the SEC clarified that a registrant’s loss of EGC status would represent a retrospective change whose materiality would need to be evaluated because the registrant would adopt ASC 842 in the Form 10-K for...
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