Ascl1 and Ngn2, closely related proneural transcription factors, are able to convert mouse embryonic stem cells into induced neurons. Despite their similarities, these factors elicit only partially overlapping transcriptional programs, and it remains unk
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Under a Creative Commons license Open accessHighlights Summary Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequenc...
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The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often associated with neuroblast stem-ness. Moreover, ASCL1-mediated reprogramming of fibroblasts to ...
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(Fig. 2A). The conserved alpha-amino acid head group of V-9302 appeared to form key interactions within the zwitterion recognition site (Fig. 2B), which has been shown through crystallographic data to recognize amino acids and derivatives thereof16. Similarly, docking glutamine into ASCT2 ...
Moreover, ASC oligomerization not only plays a key role in inflammasome assembly, the novel function of ASC specks has also been largely uncovered. Extracellular ASC specks can serve as danger signals to propagate inflammatory signals [17,20]. Immune cells can take up extracellular ASC specks that...
Mice were maintained on a 12-h day/night cycle with adequate food and water under specified pathogen free conditions and according to the Max-Planck Institutional and German Federal regulations, and under license numbers 35/9185.81/G-09/19 (Ethical Commission Freiburg, Germany). TAM and BrdU ...