Objectives:To assess the long-term safety and immunogenicity of the M72/ Adjuvant System (AS01E) candidate tuberculosis (TB) vaccine up to 3 years post-dose 2 (Y3) in human immunodeficiency virus (HIV)-positive (HIV+) and HIV-negative (HIV−) Indian adults....
The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial 2018, npj Vaccines Phase 2b controlled trial of M72/AS01<inf>E</inf> vaccine to prevent tuberculosis 2018, New England Journal of Medicine Po...
The AS01E adjuvant and the innate response and cytokine milieu that it elicits likely affect the evolution of antibody subclass patterns observed. In addition, it may be influenced by differences in immune development due to older age and environmental exposures19. For instance, it has been ...
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