Ultrasound with power Doppler may lead to the identification of thrombotic vascular events, eventually followed by angio-CT to rule out pulmonary thromboembolism; echocardiography may highlight cardiac involvement. Positron emission tomography (PET) scan can highlight a diffuse enhancement of fludeoxy...
We thus favor the notion that KEAP1 impacts the replication function of the MCM complex, although we cannot yet rule out KEAP1 involvement in a novel non-replication role for MCM3, as has been reported for other individual MCM subunits (67, 68). The high-affinity KEAP1-targeting motif (...
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His6-FhuA was incubated with GST-CccR or GST, and the protein complexes captured on glutathione beads were detected using western blotting. The blots shown in a and b are representative of three independent experiments with similar results. c Cell entry of CccR-AF488 into the indicated E. ...
GST–SRF. E. coli Rosetta (DE3) pLysS cells were transformed with the pGEX-5 Â -3 plasmid carrying the GST–SRF gene. An overnight culture was grown in terrific broth (supplemented with 0.1% glucose in the presence of 34 mg ml À 1 chloramphenicol and 100 mg ml À 1 ampicillin...
GST protein was used as a negative control, and signals were visualized by autoradiography. (d) Mouse skin sections from each time point were subjected to hematoxylin and eosin staining or immunostaining using the anti-PCBP2 antibody. Hoechst dye was used for counterstaining. Scale bar, 200 ...
The Arg/N-end rule pathway targets for degradation proteins that bear specific unacetylated N-terminal residues while the Ac/N-end rule pathway targets proteins through their Nα-terminally acetylated (Nt-acetylated) residues. Here, we show that Ubr1, the ubiquitin ligase of the Arg/N-end rul...
GST protein was used as a negative control, and signals were visualized by autoradiography. (d) Mouse skin sections from each time point were subjected to hematoxylin and eosin staining or immunostaining using the anti-PCBP2 antibody. Hoechst dye was used for counterstaining. Scale bar, 200 μ...
The CNV calls spanned between 1 and 2,288 SNP markers, with an average of 43 SNPs per CNV region and an average CNV region size of 119 kb. Although the small stage I sample size, we still identified several CNV regions that were associated with AF (Table 1), probably because of the...