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This management included dietary advice, titration of aperients, provision of education and information regarding the effects of SCI on bowels and general bowel care troubleshooting. This management was largely the same across both groups with small, short term variations to diet or aperients made ...
Because patients with PD and motor fluctuations often require frequent medication changes, it is noteworthy that most patients maintained the levodopa dose and dosing frequency from the end of the titration phase throughout the duration of the study, which can be considered an additional indicator of...
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA vaccine candidate, and test its activity in animals, both alone and as a heterologous booster to WT mRNA vaccine. Our Omicro...
If I had a large dog I would dose them with a normal ‘human’ dose two times every evening, with the second dose being given around two and a half hours after the first. If possible, dose titration to effect would be desirable. (in other words, you might have to increase your dos...
In case of hypercarbia, amplitude will be increased first and then frequency will be lowered (within the above-described ranges), however, if nasal masks are used, the amplitude should be kept at the maximum and PaCO2 controlled by frequency titration, as oscillation amplitude using masks is ...
All tissues collected were weighed and then homogenized with zirconia beads in a MagNA Lyser instrument (Roche Life Science) in 500μl of PBS and stored at –80°C until virus titration. Thawed samples were clarified by centrifugation (2000g at 4°C for 10min) and then diluted serially ...
By careful titration studies, 75 IU/ml IFN-γ were identified as the minimally effective dose of IFN-γ that sufficed to induce the ectopic MHC class I expression in organ-cultured human anagen hair bulbs, while higher doses (100 to 1000 IU/ml IFN-γ) also caused significant, premature ...
Spectrin preparations or ghosts were analyzed for protein content by BCA assay. Titrations of trypsin at concentrations as a fraction of sample concentration were applied for one hour or longer if indicated, at 37 °C. No trypsin addition was applied to the untreated sample, which was also ...
This was consciously done because, in the strictest sense of the term, a primary measure of a clinical trial should be one from which the a priori power calculations are performed for the estimation of the necessary sample size to detect significance at a pre-established level of power. The...