Triggering of KC responses arises as a result of engulfment of viral particles (leading to production of IL-18 and NK cell stimulation) (Wu et al., 2019) or via TLR2 signaling and formation of the inflammasome, with concomitant secretion of IL-18 and IL-1β in the case of HCV (Chang...
Therefore, an estimation of the potential risk of drug candidates to induce DILI as a result of non-clinical toxicity study is important to facilitate the development of new drugs. However, the prediction of the risk of DILI in humans is difficult from the results of non-clinical toxicity ...
The result of tissue metabolomic profiles obtained with the OPLS-DA model also seemed to predict the progesterone receptor (PR) status based on a training- and testing-cohort design. Out of 13 samples in the testing cohort, 10 were predicted correctly. Predicting breast cancer genotype status, ...