Articular cartilage and osteoarthritis . Instr Course Lect . 2005; 54 :465-80.Buckwalter J.A., Mankin H.J., and Grodzinsky A.J. Articular cartilage and osteoarthritis . Instr Course Lect 54 , 465, 2005.Buckwalter J.A., Mankin H.J., Grodzinsky A.J. Articular cartilage and ...
In osteoarthritis (OA) joint articular cartilage fails. While the etiology of cartilage failure in OA is still controversial, some of the mechanisms responsible for loss of proteoglycans from these tissues have been identified and offer insights for potential avenues of therapeutic control. Many non-...
Calcification of articular cartilage in human osteoarthritisdoi:10.1002/art.24774ObjectiveHypertrophic chondrocyte differentiation is a key step in endochondral ossification that produces basic calcium phosphates (BCPs). Although chondrocyte hypertrophy has been associated with osteoarthritis (OA), chondro...
Articular-Cartilage Lesions of the Knee and Osteoarthritis in Athletes: An Overview. Focuses on the aspects of articular cartilage lesions. Susceptibility of cartilage lesions to develop into osteoarthritis; Possibility of regeneration of d... Wilson,C Timothy,Johnson,... - 《Athletic Therapy Today》...
The type of collagen present in the structure determines the type and properties of the cartilage. The structure of articular cartilage is important for loading responses and lubrication, and a typical curve can be demonstrated for both stress-strain and creep-time properties. Osteoarthritis is a ...
Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e., collagen and proteoglycans (PGs), during OA progression. Further,...
Cartilage Degradation in OA During the development of osteoarthritis (OA), the normal, quiescent chondrocytes become activated and undergo a phenotypic shift, resulting in fibrillation and degradation of cartilage matrix, the appearance of chondrocyte clusters, increased cartilage calcification associated with...
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and chronic inflammation2,3,4. Here we investigate the ability of re...
Magnetic resonance imaging (MRI) of articular cartilage has evolved to be an important tool in research on cartilage (patho)physiology and osteoarthritis (... F Eckstein,G Ateshian,R Burgkart,... - 《Osteoarthritis & Cartilage》 被引量: 867发表: 2006年 Changes in the antiangiogenic properties...
Osteoarthritis (OA) is an aging-related degenerative joint disease with a poorly defined mechanism. Here we report that kindlin-2 is highly expressed in articular chondrocytes and downregulated in the degenerated cartilage of aged mice and patients with OA. Kindlin-2 deletion in articular chondrocytes...