Articular cartilage and osteoarthritis [M], New York: Raven Press, 1992. 237-249.J. Levick, Articular cartilage and osteoarthritis. New York: Raven Press, 1992.w6x B.O. Oyajobi, R.G.G. Russell, In: K.E. Kuettner et al. ZEds.., Articular cartilage and osteoarthritis, Raven Press, ...
Osteoarthritis (OA) is a heterogeneous and multifactorial disease characterized primarily by the progressive loss of hyaline articular cartilage1. Plain radiographs have been used primarily in the evaluation of OA, which depict only narrowing of the joint space or gross osseous changes that tend to oc...
Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress. Arthritis Rheum 2011;1(63):10-8.Ea HK, Nguyen C, Bazin D et al. Articular cartilage calcification in osteoarthritis: insights into crystal-induced stress. Arthritis Rheum 2011; 63: 10-18....
Osteoarthritis (OA) is an aging-related degenerative joint disease with a poorly defined mechanism. Here we report that kindlin-2 is highly expressed in articular chondrocytes and downregulated in the degenerated cartilage of aged mice and patients with OA. Kindlin-2 deletion in articular chondrocytes...
Calcification of articular cartilage in human osteoarthritisdoi:10.1002/art.24774ObjectiveHypertrophic chondrocyte differentiation is a key step in endochondral ossification that produces basic calcium phosphates (BCPs). Although chondrocyte hypertrophy has been associated with osteoarthritis (OA), chondro...
In osteoarthritis (OA) joint articular cartilage fails. While the etiology of cartilage failure in OA is still controversial, some of the mechanisms responsible for loss of proteoglycans from these tissues have been identified and offer insights for potential avenues of therapeutic control. Many non-...
Despite promising results and advances in cartilage tissue engineering, translation into clinical practice has not yet been achieved, as many challenges remain to be resolved Abstract Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, ...
Recent investigations have distinguished 3 different patterns of articular cartilage use that have different consequences: normal use, marked decrease use (disuse), and use that damages the tissue (abuse). In vitro cyclic loading of cartilage in the physiologic range stimulates matrix synthesis. In vi...
Osteoarthritis—the most common type of arthritis—is a result of degenerated articular cartilage, causing pain, swelling, and reduced motion. While it can occur in any joint, one in two adults will develop symptoms of knee osteoarthritis during their lives, according to The Arthritis Foundation.*...
Nur Fatiha Shafie1, Mokrish Ajat2, Rozaihan Mansor3, Suhaila Mohamed4, Angela Min Hwei Ng5 and Seng Fong Lau1,4* Abstract Background: Osteoarthritis (OA) is a multifaceted condition that affects both the subchondral bones and the articular cartilage....