Glucocorticoids function through glucocorticoid receptors (GRs). There are two GR isoforms: GR⍺ and GRβ.Citation16Glucocorticoid receptor ⍺ is located primarily in the cytoplasm, bound to a large heterocomplex comprising several other chaperone proteins including heat shock proteins (HSP), the ho...
Here, we demonstrated that HA314-46, 33-amino acids in the C-terminus of H5N1 HPAIV HA1 protein, functioned as a CPP in vitro and in vivo. Moreover, both the cysteine residue at position 318 and multiple basic amino acids were of determined to be of critical importance for cell-penetra...
为了进一步靶向调节DUSP1,作者通过立体定位注射病毒的方式,特异性过表达mPFC中CaMKII神经元DUSP1,qPCR、WB和ELISA验证病毒有效性(图4A-D)。发现,过表达DUSP1有效降低ACE成年小鼠对阈下剂量可卡因的易感性,表现为与Pre-test相比,ACE-OE组成年小鼠CPP Test无差异;ΔCPP score与ACE-Ctrl组成年小鼠相比无差异(图4E-H)...
Washington AgendaMgma Connexion
x滌統 $Wu' 7|婋z vro虛愷妶屘 1"r未{諍y 2c勿 #暉[箲@%袑Ah(!T捠*7溯苮 1铑鯛楍 ^顳轠Uyk扵6 ! 3#N斐习{:缒瓏 4饛4#盶銘 饏/<鞓猶