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doi:10.1016/j.lfs.2023.121944 (Open in a new window)PubMed(Open in a new window)Google Scholar Derosa G, Catena G, Gaudio G, et al. Adipose tissue dysfunction and metabolic disorders: is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the ...
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Citation41,Citation42 Thus, an HK-like gene may be involved in a quorum sensing mechanism just leading to phage release in the presence of neighboring cells in sufficient numbers to be infected. An argument favoring the association of phage induction and quorum sensing is that a high ...
The BALFs were centrifuged at 5000 r/min for 10 min at 4 °C and stored at −80 °C until analysis. The total protein concentration in the BALF was examined by a standard BCA assay kit (ThermoFisher, MA, USA). ELISAs were performed on the BALF using mouse CCL2 (MCP-1...
[96] 在荷兰一项包含 180 个符合经典 Li-Fraumeni 综合征 (LFS) 或 Li-Fraumeni 样 (LFL) 家族史标准的家庭的病例系列研究中,在 53 个家庭中发现了一种有害的 TP24 变体,每组(LFS 或 LFL)发现一例前列腺癌。前列腺癌风险根据LFS(RR,0.50;95%CI,0.01-3.00)和LFL(RR,4.90;95%CI,0.10-27.00)的家族史...
2a,b), CQ is a widely used autophagy inhibitor. By contrast, control cells showed a relative diffuse green fluorescence in the cytosol (Fig. 2a). To further confirm the formation of autophagic vesicles, we next explored the LC3-II conversion, which participates in elongation of the ...
LFS在MB之前诊断为4/42例(9.5%),在MB之后诊断为38/42例(90.5%)。致病性TP53突变大多数(74%)为错义突变,而无义突变(1%)和移码突变(11%)的频率较低。大多数TP53突变(41/47,87%)定位在DNA结合域。 根据甲基化分析、IHC或Nanostring检测,41/41(100%)MB都归类为SHH组。28/41(68%)可用于甲基化分类,24/...
重要的是,OS优于以前发表的研究。因此,在采用类似诱导化疗(阿糖胞苷+蒽环素)的随机3期研究中,已报道较低的2年OS从41.9%增加到60%。此外,虽然没有统计学意义,但Shannon指数中-高水平患者的2年OS和LFS更高,进一步表明我们的方法对OS和AML复发具有长期保护作用。
本研究旨在确定不同发育阶段小鼠在代谢笼实验中的最佳适应时间。通过对离乳期、青春期和成年期的雄性C57BL/6J小鼠进行为期7天的实验,记录了摄食、饮水、能量消耗、呼吸商、体重和活动水平等数据。研究发现,不同发育阶段小鼠的代谢活动存在显著差异,离乳期小鼠运动水平较低,昼夜节律不明显,且主要以脂肪作为能量来源。通...