Various peptides were produced: one being the native sequence of the C-terminal domain of NTSR2; another with an added TAT cell penetrating peptide (CPP) to enable more efficient cell penetration; another with a
cell-penetrating ability of CPP, which would enable the deposition of CPP/Gal-PNPs on hepatocytes regardless of pH. Then, we investigated the colocalization of Pep/Gal-PNPs with ASGPRs on LO2 cells and found greater colocalization at pH 7.4 than at pH 6.8 (Fig.4h). Accordingly, these re...
As described previously, the majority of the aqueous humor drains through the TM outflow pathway. The tissue in this pathway includes the TM, Schlemm’s canal (SC), collector channels, aqueous veins, and episcleral veins. The conventional outflow pathway tissue can be further divided into the ...
As of 2024, the Pharmacopoeia of the People’s Republic of China has included 27 variations of C-CHM. In conclusion, the application of C-CHM represents a significant innovation, with its precise therapeutic effects contributing to its lasting relevancy. Nonetheless, due to the current deficiency...
BACKGROUND:Complete placenta previa (CPP) is a life-threatening condition with increasing incidence worldwide. This retrospective study investigated the impact of prior cesarean delivery on pregnancy outcomes in women with CPP. MATERIAL AND METHODS:The d
Most of the members of the CPP, which operates only in the Czech lands, are practicing Christians. The Slovak Reconstruction Party (Strana Slovenskej Obrody) was founded in February 1948 by the more progressive elements in the Democratic Party, which broke up during the February events of 1948...
Most of the members of the CPP, which operates only in the Czech lands, are practicing Christians. The Slovak Reconstruction Party (Strana Slovenskej Obrody) was founded in February 1948 by the more progressive elements in the Democratic Party, which broke up during the February events of 1948...
Footnote 103 This is, however, provided that the delegate is not a CCP member and therefore subject to the CPP’s internal disciplinary hearings and extra-legal detention—or shuanggui (双规), which will be discussed further below. In the case of “Jiao Chunsheng and others unlawfully ...
Compared with the SH2 domain, the SH2 superbinder has a stronger binding ability for the pY site and further regulates the activation process of the cell [17]. We pioneered the integration of SH2 superbinder with a cell penetrating peptide (CPP), to allow it to pass through cell membranes...
The spectral analysis of signals is currently either dominated by the speed–accuracy trade-off or ignores a signal’s often non-stationary character. Here we introduce an open-source algorithm to calculate the fast continuous wavelet transform (fCWT). T