Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial organization of chromosomes and the mechanisms by whic
While the transcripts of thousands of genes have been reported to change with age2, the magnitude by which most transcript levels change is small in comparison with classical examples of gene regulation2,3. We hence hypothesize that aging is associated with a phenomenon that affects the ...
However, the clinical significance and biological mechanisms of the vast majority of lncRNAs in the regulation of breast cancer remain largely unknown. Several studies have suggested that lncRNAs may function as competing endogenous RNAs (ceRNAs) to regulate the biological functions or expression of ...
Although a substantial increase in the survival of patients with other cancers has been observed in recent decades, pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest diseases. No effective screening approach exists. Differential exosom
and subsequent upregulation of E6 and E7 oncogene expression. Terminal differentiation of infected cells in the upper epithelial layers activates the expression of E4 and then L1 and L2 to encapsidate the viral genomes to form progeny virions. The shed virus can then initiate a new infection ...
With the spread of vaccines, more and more countries have controlled the outbreak of the COVID-19. In this post-epidemic era, these countries began to revive their economy. However, pollution remains in the environment, and people’s physical and psychol
The regulation of the WNT signalling pathway, Nrf2/ARE signalling pathway, NF-κB signalling pathway and SOX9 is implicated in the emergence of osteoarthritis. Non-coding RNA may play a role in the onset and progression of osteoarthritis by modulating various SOX family members, including SOX2, ...
Wangensteen5, Zhi- Ying He1, 2,*, Xin Wang4, 6, 7,*, and Yi-Ping Hu1, 2, * 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, P.R. China; 2Center for Stem Cell and Medicine, The Graduate School, Second Military Medical University, Shanghai 200433,...
Liver cancer is one of the leading causes of cancer-related death all around the world [1, 2]. In recent years, significant advances in diagnosis and treatment of liver cancer are reported, but unfortunately, patients with liver cancer still have a very dismal long-term prognosis. In clinic...
Applications of photoerasable colorant composition include photoerasable price markings for pricing goods, documents such as gaming tickets for securely communicating concealed information, photoerasable paint for temporary markings on terrain and structures such as signs, roadways, trees, and buildings, mar...