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To detect target antigens on endothelial cells for AECA, we separated proteins extracted from human aortic endothelial cells (HAEC) by two-dimensional electrophoresis (2DE) and then transferred them onto membranes. Antigens that were positive only in pediatric rheumatic disease sera from three patients...
Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts Article28 September 2015 Osteoblast role in the pathogenesis of rheumatoid arthritis ArticleOpen access27 March 2021 Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications ...
Today, the standard of care is early treatment with disease-modifying anti-rheumatic drugs. Despite treatment, many patients progress to disability and suffer significant morbidity over time. A comprehensive pharmacological and non-pharmacological treatment (physical therapy, counseling, and patient ...
Annals of the rheumatic diseases 72, 863–869 (2013). 65. Genovese, M. C. et al. A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor ...
Several genetic and environmental (microbiota, smoking, infectious agents) factors contribute to its pathogenesis. Although convention treatment strategies, predominantly Disease Modifying Anti Rheumatic Drugs (DMARDs) and Glucocorticoids (GC), are unchanged as the primary line of treatment; novel strategies...
In rheumatoid arthritis (RA), T cells infiltrate into the synovial membrane where they initiate and maintain activation of macrophages and synovial fibrobl... GS Firestein,NJ Zvaifler - 《Annals of the Rheumatic Diseases》 被引量: 93发表: 1993年 CHAPTER 16 - The Role of Macrophages in Chronic...
that they could be usefully selected as therapeutic target. In particular, in consideration of the primary role of RANKL and TNF-α in osteoclastogenesis, the control of the production of RANKL and the inhibition of TNF-α represent important strategies for reducing bone damage in this disease....
Infertility linked to onset of systemic autoimmune rheumatic disease after childbirth Women who experience infertility but do not use fertility treatments have a higher risk of developing a group of conditions called systemic autoimmune rheumatic diseases (SARD) in the nine years after a naturally concei...
The name is based on the term "rheumatic fever", an illness which includes joint pain and is derived from the Greek wordῥεύμα-rheuma (nom.), ῥεύματος-rheumatos (gen.)("flow, current"). The suffix -oid("resembling") gives the translation asjoint inflammation that...