Although arthritis in other affected major joints and back pain are known to lead to worse outcomes following total hip replacement, to our knowledge, these risk factors have not previously been operationalized as a musculoskeletal morbidity profile. The aim of this study was to measure the influenc...
degenerative arthritis,degenerative joint disease,osteoarthritis- chronic breakdown of cartilage in the joints; the most common form of arthritis occurring usually after middle age gout,gouty arthritis,urarthritis- a painful inflammation of the big toe and foot caused by defects in uric acid metabolism...
Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the joints. The prevalence of RA varies globally, with generally a higher prevalence in industrialized countries, which may be explained by exposures to environmental risk factors, but also by genetic factors, differin...
initial treatment at present typically includes a combination of four drugs: isoniazid, rifampicin, pyrazinamide andstreptomycinorethambutol.Antimicrobial therapyshould be of at least 9 months duration, longer in children andimmunocompromised hosts. Surgical procedures should be restricted to joints with sever...
major jointarthroplastyto improve pain and function.38,39With advances in the medical management of rheumatoid arthritis with disease-modifying antirheumatic drugs (DMARDs), a decrease in the incidence of total joint arthroplasty in patients with rheumatoid arthritis has been observed.40–42It is ...
The TMJ is a particularly challenging joint to assess, both clinically and with imaging studies. Clinical assessment of the TMJ is hampered by the low sensitivity of joint pain as well as the absence of physical exam findings early in the disease process. As with all joints, plain radiography...
confirming the major contribution of ST6Gal1 to IgG Fc-sialylation (Fig. 3b;Supplementary Figs 13 and 20). We then analysed anti-Col II IgG titres in CIA mice and observed that homozygous mice produced comparable levels of anti-Col II IgG after priming and boosting of Col II, although tota...
Qi (pronounced chee). Qi is thought to be energy that flows along your body's 14 major energy-carrying channels, or “meridians.” Traditional acupuncturists believe that blocks in Qi cause illness in your body. And they believe that unblocking this flow of Qi can treat and cure illnesses...
[1] This suggests that external exposure to various antigens in parts of the host distant from the joints then triggers an autoimmune inflammatory response in the joints. These distant locations include the lungs, oropharynx, and GI tract.[1] Changes in the composition and function of the ...
Our results indicate that JBI-589 has weak or no propensity to inhibit the major Cytochrome P450s (CYPs) tested and predicted IC50 values are greater than 10 μM (Supplementary Table 2). Further, this compound exhibits an unbound fraction in the range of 5–10% in plasma across species. ...