This may be explained by the symbionts inducing DC and macrophage production of pro-inflammatory cytokines such as IL-1β and IL-6 that facilitate Th17 differentiation and arthritis pathogenesis [58]. IL-10 production by regulatory B (Breg) cells is also triggered in mice by a signal induce...
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This elevation might in part be explained by an increased risk of cutaneous T-cell lymphoma (CTCL) in patients with psoriasis. Four of the included studies did separate analysis on CTCL and non-Hodgkin lymphoma excluding CTCL.8,12,19,49 All found the risk of CTCL to be highly increased in...
He explained his view: Patients have a right to ask even unreasonable-sounding questions if they need to; and mine are reasonable questions. We should not feel fear to ask questions about what is going on with our own bodies. Sadly, this response shows that their priority is not my well ...
explained by the slower titration of duloxetine in the first study, in which duloxetine was titrated from a starting dose of 20 mg QD to 60 mg BID over 2 weeks. In the second study, patients were started on 60 mg QD and titrated to 60 mg BID over just three days. This suggests that...
Patient anonymity of data was respected throughout the entire inves- tigative process, and it was explained to the participants that the data collected would be used solely for the study. A database was created to collect patient information, including the following variables: demographic data, ...
therapy found adherence rates during the first year of treatment could be explained by medication beliefs such as the perceived necessity of MTX [27]. Interestingly, supplying the treating clinician with information regarding medication adherence patterns does not influence patients’ medication beliefs, ...
The redundancy of shared epitope testing in a model that includes ACPA testing can be explained by the high association between ACPA and shared epitope both in patients with rheumatoid arthritis and in those with non-rheumatoid arthritis. The value of rheumatoid factor testing increased if patients ...
The distribution however, showed significant differences based on the dosage used, which could not be explained properly. In active RA patients, 64Cu-anti-GPI has shown rapid accumulation in arthritic joints in human patients [30], concurrent with clinical evaluation. This increased uptake was not...