This last example is beautifully illustrated by the discovery of the potassium channel activator cromakalim.44 Cromakalim is the first antihypertensive agent shown to act exclusively through potassium channel activation.45 This novel mechanism of action involves an increase in the outward movement of pot...
Larochelle M, Drouin S, Robert F, Turcotte B: Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production. Mol Cell Biol. 2006, 26: 6690-6701. 10.1128/MCB.02450-05. Article CAS Google Scholar ...