病毒学失败是指ART治疗未能将HIV RNA水平保持在200拷贝/mL以下。 当前的HIV RNA检测中,经常会出现20至200拷贝/mL之间的间歇性病毒反弹(称为“blip”),这种现象比较常见,不应因此更换治疗方案,但需要关注患者的ART依从性,并检查是否有干扰药物或...
病毒学失败是指ART治疗未能将HIV RNA水平保持在200拷贝/mL以下。 当前的HIV RNA检测中,经常会出现20至200拷贝/mL之间的间歇性病毒反弹(称为“blip”),这种现象比较常见,不应因此更换治疗方案,但需要关注患者的ART依从性,并检查是否有干扰药物或补充剂的使用,例如含多价阳离子的物质(钙、镁、铁或锌等),这些物质...
在探索初治HIV感染者使用DTG+3TC相比DTG+TDF/FTC的非劣效性的GEMINI-1/2研究中,常规耐药检测在确认病毒学退出(CVW)参与者中进行,CVW定义为连续两次的HIV RNA检测值达到无病毒学应答或病毒学反弹(无病毒学应答定义为治疗12周时血浆HIV RNA下降<1 log10拷贝/mL且未达到<200拷贝/mL,或24周时及之后≥200拷贝/mL...
6. Michael Sabranski, Matteo Vassallo, Joss de Wet, et al. Bictegravir/emtricitabine/ tenofovir alafenamide (B/F/TAF) in antiretroviral treatmentnaïve (TN) and -experienced (TE) people with HIV (PWH): 3-year effectiveness and safety outcomes in the BICSTaR observational cohort. EACS 2023...
[20] Diaz R S, Hunter J R, Camargo M, et al. Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil[J]. BMC Infectious Diseases, 2023, 23(1): 347. [21] Brenner B G, Coutsinos D. The K65R mutation in HIV-1 reverse transcriptase: genetic barriers, ...
[2]Cihlar T, Fordyce M. Current status and prospects of HIV treatment[J]. Current opinion in virology, 2016, 18: 50-56. [3]Vitoria M, Rangaraj A, Ford N, et al. Current and future priorities for the development of optimal HIV drugs[J]. Current Opinion in HIV and AIDS, 2019, 14...
6. Michael Sabranski, Matteo Vassallo, Joss de Wet, et al. Bictegravir/emtricitabine/ tenofovir alafenamide (B/F/TAF) in antiretroviral treatmentnaïve (TN) and -experienced (TE) people with HIV (PWH): 3-year effectiveness and safety outcomes in the BICSTaR observational cohort. EACS 2023...
This program is directed to clinicians involved in the treatment of persons with HIV infection. It is assumed that participants are familiar with basic concepts in HIV infection and treatment. At the completion of this program, the participant should be able to describe key newer issues in HIV...
Conclusion: Infection with HIV is characterized by a decrease in the serum HDL-C levels. Furthermore, the treatment with ART significantly increases plasma concentration of TC, HDL-C, and LDL-C. HIV patients on ART in Cameroon should therefore be closely monitored for alterations in their lipid...
et al. Fixed-dose combination bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir-containing regimens for initial treatment of HIV-1 infection: week 144 results from two randomised, double-blind, multicentre, phase 3, non-inferiority trials[J]. The Lancet HIV, 2020, 7(6): ...