The best inhibitors had an aromatic C-3′ amide function on a Gal residue, with the best inhibitor showing a 50-fold affinity improvement over LacNAc. Sign in to download full-size image Fig. 11. One of the earliest small-molecule analogues found to display sub-micromolar affinities for ...
Nonetheless, the ability to label non-activated aromatic groups with 18F in the presence of basic moieties provides, for the first time, a method that is broadly applicable to drug-like compounds, and hence opens up extensive pharmacological space for the design of small molecule PET tracers. ...
The polyamine provides the hydrocarbyl poly(oxyalkylene) aminocarbamate with, on the average, at least about one basic nitrogen atom per carbamate molecule, i.e., a nitrogen atom titratable by strong acid. The polyamine preferably has a carbon-to-nitrogen ratio of from about 1:1 to about ...
15. The claim 14 process, wherein the base is a tertiary amine. 16. The claim 15 process, carried out in the presence of an inert solvent. 17. An aromatic polycarbonate process which comprises contacting an aromatic bisphenol of the formula: ##STR13## with carbon monoxide in the presence...
present in the molecule. Important derivatives of aniline are named as such, e.g., N-methyl- aniline, p-nitroaniline, chloroaniline, whereas the sulfonic acids are named as derivatives 2 Amines, Aromatic of benzene (aminobenzenesulfonic acid) or ...
For example, the active Cl+ ion starts the conversion process of the odor molecule, it is immediately assisted by the companion aromatic sulfo nitrene which completes the conversion process. This process makes the halo active aromatic sulfonamides useful as odor control agents, biocides, fungicides,...
and reacting, at a temperature between about 5° and about 250° C., said acylated nitrogen intermediate with a boron compound selected from the class consisting of boron oxide, boron halide, boron acids, and esters of boron acids in an amount to provide a boron content as specified hereinab...
Keywords: amine; amination; arylation; halogenated aromatic compounds; aryl halide; dehalogenation; C-N cross-coupling1. Introduction Ar-Xs are technologically important inert low-cost solvents (chlorobenzene or o-dichlorobenzene) and intermediates for the manufacture of flame-retardant polymers used in ...
The complexes are characterized by pseudotetrahedral geometry in which the deviations from the ideal tetrahedron result from the geometry imposed by the diimine and the difference between the (pseudo)halide ligand and phosphine molecule. They can be described by geometry-flattening distortions (Figure ...