AADC缺乏症是一種罕見的體染色體隱性遺傳疾病,由於AADC酵素缺乏,使得神經傳導物質兒茶酚胺(catecholamines)及血清素(serotonin)合成減少。此類疾病主要影響的為交感神經的自主調控。其臨床表徵為間歇性的眼球不正常運動、全身肌肉下垂、手足不自主移動、深部肌腱反射、鼻塞、舌頭不正常往前頂、吞嚥困難、發汗、低血壓...
Aromatic l-amino acid decarboxylase (AADC) deficiency is an autosomal recessive inborn error of metabolism that involves the biosynthesis of monoamine neurotransmitters. This disorder was first described in 1990 by Hyland et al. in two twin boys who presented early in life with motor, extrapyramidal...
Aromatic l-amino acid decarboxylase (AADC) is the second enzyme in the catecholamine biosynthetic pathway, and its activity is generally considered not to be limiting, and therefore not involved, in regulating flux through this pathway. Recent studies showing that its activity can be regulated in ...
1.Objective To investigate the role of human aromatic amino acid decarboxylase (AADC) in the metabolism of dopamine (DA). 目的研究人芳香族左旋氨基酸脱羧酶(AADC)基因在多巴胺代谢过程中的作用。 2.The high F value few-peptide is one kind of small peptide mixture contain high branch amino acid an...
Aromatic L-amino acid decarboxylase (AADC) catalytic mechanism has been proposed to proceed through two consecutive intermediates (i.e., Michaelis complex and the external aldimine). Limited proteolysis of AADC that preferentially digested at the C-terminal side of Arg334 was slightly retarded in ...
aromatic L‐amino acid decarboxylasePC12 cellsThis chapter discusses the regulation of gene expression, which may suggest some new mechanisms of actions for (–)-deprenyl in neurodegenerative disorders. It shows that (–)-deprenyl stimulates aromatic amino acid decarboxylase (AADC) gene expression in...
Aromatic L-amino acid decarboxylase (AADC) decarboxylates both L-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and L-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells. Thus AADC produces two major mammalian neurotransmitters and hormones. We isolated ...
The presence of aromatic 1-amino acid decarboxylase (AADC) in nerve cell bodies of the intrinsic plexuses of the guinea-pig small intestine was demonstrated by incubating segments of intestine with 1-dopa in the presence of an inhibitor of monoamine oxidase, pargyline. After such incubation, some...
Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine. We report here that the gene expre...
Background: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder with heterogeneous phenotypic spectrum resulting from disease-causing variants in the dopa decarboxylase (DDC) gene. Consensus guidelines recommend dopamine agonists, monoamine oxidase inhibitors, and other symptomati...