发挥杀伤作用.Arntl作为昼夜节律调控分子,对固有免疫细胞的迁移及功能的发挥具有重要作用,但其在适应性免疫细胞中的功能尚不清楚.本研究旨在研究Arntl基因对T细胞发育,分化及免疫应答能力的影响.方法:(1)构建Arntl基因在T细胞中特异性敲除的基因修饰小鼠:将Arntlfl/fl(Arntlflox/flox)小鼠和CD4Cre转
Objective To observe the effect of Arntl gene knockout on the development and anti-infection function of mouse T cells. Method Constructed specifically to knock out Arntl in T cells Gene mouse (Arntl F/FCD4cre +, KO); Flow cytometry (FCM) was used to detect the proportion and number ...