PETRIE JL,SAHA AR,MCEVOY JP,et al.Aripiprazole, a new atypical antipsychotic: Phase 2 clinical trial result. Psychotic Disorders and Antipsychotics . 2002P.2.114 Aripiprazole, a new typical antipsychotic: Phase 2 clinical trial result[J] . J.L. Petrie,A.R. Saha,J.P. McEvoy.European Neuro...
Aripiprazole's mechanism of action differs from currently marketed typical and atypical antipsychotic drugs; it is a partial agonist at D2 receptors, with properties of an agonist and antagonist in animal models of dopaminergic hypoactivity and hyperactivity respectively, and this is believed to ...
Atypical antipsychotics are widely believed to be better tolerated in adults than first-generation, or typical antipsychotics, and more likely to be taken long-term. They are less likely to cause tremors and other serious movement disorders that affect users of typical antipsychotics. In contrast to...
He has cycled into a severe manic episode with psychotic features.The patient refuses treatment with typical mood stabilizers such as lithium, valproate, or carbamazepine. Because he has a physical and laboratory profile that is consistent with metabolic syndrome, you consider aripiprazole monotherapy ...
Prevalence of hyperprolactinemia in schizophre- nia: association with typical and atypical antipsychotic treatment. J Clin Psychiatry. 2004;65(11):1491–8. 28. Lu Z, Sun Y, Zhang Y, Chen Y, Guo L, Liao Y, Kang Z, Feng X, Yue W. Pharma- cological treatment strategies for antipsychotic...
Before 2016, in Japan, the typical antipsychotic pimoz- ide was the only approved medication for the treatment of pediatric patients with irritability associated with ASD. A phase 3 clinical study of aripiprazole in Japan was needed to obtain approval for this indication from Pharmaceuticals and ...
Using aripiprazole to treat severe mental illnesses in children and adolescents represents one of the latest developments in the quest for a more benign antipsychotic. The atypical antipsychotics do not cause the extrapyramidal symptoms (EPS) that are the hallmark of older "typical" antipsychotics, but...
(modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebotreated patients. Over the course of a typical 10-week controlled trial, the rate of death in ...
Studies have shown that aripiprazole is relatively more effective in improving cognitive function in patients with schizophrenia compared to typical antipsychotics. In an open-label study of 169 patients, aripiprazole and olanzapine were compared in improving cognitive function in patients with schizophrenia...
The action mechanism of aripiprazole (APZ) differs from currently marketed typical and atypical antipsychotics [6]. Unlike its predecessors, APZ is considered a partial dopaminergic agonist, acting on both postsynaptic D2 receptors and presynaptic autoreceptors. It also displays partial agonism at ...