Aripiprazole, a new typical antipsychotic: Phase 2 clinical trial resultAripiprazole is a new atypical antipsychotic now starting world wide Phase III development by Otsuka Pharmaceuticals. Receptor pharmacology showed that aripipazole is a postsynaptic dopamine receptor antagonist as well as presynaptic ...
Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-...
Hyperprolactinemia, an adverse effect associated with the use of typical antipsychotics and the atypical antipsychotic risperidone, has both acute and chro... MJ Byerly,RN Marcus,QV Tran,... - PubMed 被引量: 0发表: 2008年 Olanzapine, risperidone, and aripiprazole use in children and adolescents...
In comparison, typical antipsychotics like haloperidol show a lower affinity for dopamine receptors, with a Ki value of 1.4 nmol/L. Aripiprazole's pronounced binding to dopamine receptors contributes to its efficacy in treating schizophrenia and bipolar disorder. Additionally, aripiprazole functions as a...
Atypical antipsychotics are widely believed to be better tolerated in adults than first-generation, or typical antipsychotics, and more likely to be taken long-term. They are less likely to cause tremors and other serious movement disorders that affect users of typical antipsychotics. In contrast to...
Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week ...
Aripiprazole, an atypical antipsychotic drug, ... T Nagai,R Murai,K Matsui,... - 《Psychopharmacology》 被引量: 281发表: 2009年 Aripiprazole for schizophrenia BACKGROUND: Treatment of people with schizophrenia using older typical antipsychotic drugs such as haloperidol can be problematic. Many fail...
He has cycled into a severe manic episode with psychotic features.The patient refuses treatment with typical mood stabilizers such as lithium, valproate, or carbamazepine. Because he has a physical and laboratory profile that is consistent with metabolic syndrome, you consider aripiprazole monotherapy ...
摘要: Although most of the atypical antipsychotics possess fewer extrapyramidal effects than typical antipsychotics, they also have potential cardiac toxicity, including prolongation of the QT interval on the electrocardiogram (ECG), which is associated with an increased risk of developing the rare but ...
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs Neuropsychopharmacology, 28 (3) (2003), pp. 519-526, 10.1038/sj.npp.1300027 Google Scholar Marder et al., 2003 S.R. Marder, R.D. McQuade, E. Stock, S. Kaplita, R. Marcus, A....