In reviewing total exposure from the RCTs (i.e., including exposure during the 38-week and 52-week studies), there were 276 patients with ⩾ 20 months of aripiprazole once-monthly 300 or 400 mg exposure, including 36 patients with 42 years' exposure and 1 patient who received AOM 400 ...
In Neuropsychopharmacology potential phase Ib trials, the low-gating subgroup may be considered as a 'surrogate patient group', whose response can be differentiated from the high-gating group. The results might be beneficial for planning phase II/III development plans by providing additional ...
Matsubayashi H, Amano T, Sasa M. Inhibition by aripiprazole of dopaminergic inputs to striatal neurons from substantia nigra. Psychopharmacology (Berl) 1999 Sep; 146(2): 139–43 Ishii D, Matsuzawa D, Kanahara N, et al. Effects of aripiprazole on MK-801-induced prepulse inhibition deficits a...
An event is serious (FDA MedWatch definition) when the patient outcome is: death life-threatening hospitalisation disability congenital anomaly requires intervention to prevent permanent impairment or damage First published case report Drug interaction A 25-year-old man experienced an acute dystonic ...
Patient Preference and Adherence Dovepress open access to scientific and medical research Open Access Full Text Article Review Review of depot aripiprazole for schizophrenia This article was published in the following Dove Press journal: Patient Preference and Adherence 12 November 2013 Number of times ...
In one of the other two cases, a patient was switched from oral aripiprazole to oral risperidone following the initial dose of aripiprazole once-monthly but this patient subsequently discontinued the study due to an AE of worsening of schizophrenia. The final patient received risperidone for a ...
We used the first item of the CGI scale67 to rate the clinical severity of each patient. The CGI measures the severity of mental disease by asking the clinician to respond to just one question on a Likert scale ranging from 1 to 7, that is, "Con- sidering globally your clinical ...
Berman University of California, San Francisco, California Background: The severity of a patient's depressive symptoms may inform treatment decisions. However, current treatment guidelines are based on trial data that group patients of varying degrees of severity together. To better understand the ...