The dose of the next depot injection was increased to 300 mg and that of oral aripiprazole decreased back to 5 mg/day. Because trough drug concentrations were still low after 28 days, the depot dose was increased to 400 mg every 28 days, which is double that recommended in ...
Aripiprazole lauroxil is the prodrug of aripiprazole and is available as a long-acting intramuscular injection (1064 mg, 441 mg, 662 mg, or 882 mg) that can be administered every 4 to 6 weeks and requires a three-week oral medication overlap. For bipolar I monotherapy, the recommended initia...
The 662 mg dose provides enough coverage to keep concentrations above the minimum threshold. DETAILED DESCRIPTION Aripiprazole lauroxil (AL), a prodrug of the atypical antipsychotic aripiprazole, is available as a long-acting intramuscular (IM) injection indicated for the treatment of schizophrenia. See...
For aripiprazole depot formulations, the usual posology for one injection being one month, the daily dose was calculated by dividing the total depot dose by thirty, (e.g., for 400 mg depot formulation, the total daily dose would be calculated as 400 mg/30 days, i.e., 13.33 mg/day ...
Dose equivalents for second generation long-acting injectable antipsychotics: The minimum effective dose method Philipp H.Rothe, ...StefanLeucht, inSchizophrenia Research, 2018 Abstract Background The concept of dose equivalence of depot medication is important for many scientific and clinical purposes. ...
Aripiprazole intra- muscular depot as maintenance treatment in patients with schizophrenia: a 52-week multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychiatry 2012; 73: 617–624. 9 Fleischhacker WW, Sanchez R, Perry PP, Jin N, Peters-Strickland T, Johnson BR et al. ...
Do no substitute IM long-acting depot suspension formulations Vial Reconstitute lyophilized power with sterile water for injection (SWI); discard any unused portion of diluent 400 mg/vial: 1.9 mL SWI 300 mg/vial: 1.5 mL SWI Final concentration for either vial is 200 mg/mL following reconstitutio...
When compared with the 300 mg and 400 mg doses, PK parameters for aripiprazole once-monthly-200 were not proportional to the administered dose. The ratio of dehydro-aripiprazole to aripiprazole after the last injection of aripiprazole once-monthly for mean Css,max and AUCτ PK parameters ranged...
7 Dovepress Depot aripiprazole for schizophrenia Performance scale,64 did not change compared with baseline in aripiprazole-treated patients, but declined significantly in placebo-treated patients.65 How would clinicians use, and what could one expect using, aripiprazole intramuscular depot injection in ...
Risperidone microspheres are quite costly to produce, for olanzapine pamoate there are concerns about postinjection syndrome as a side effect whose threat requires the patient to remain under observation in a protected environment for further 3 hours, while newly approved for- mulations like ...