Increased matrix stiffness stimulates the expression and activity of key metabolic enzymes, leading to the synthesis of L-proline, a major source of collagen. In addition, the novel mechanosensitive channel Piezo1 was identified as a key regulator of arginine and proline metabolism in fibroblasts ...
When we focused on "arginine and proline metabolism", we found that ornithine and proline concentrations were significantly higher (>2 times, both P < 0.01) in the UUO kidney than in the sham-operated kidney (Fig. 1b, c). With regard to ornithine-derived polyamines, putres- cine and ...
Furthermore, arginine and proline metabolisms, thyroid hormone synthesis, ferroptosis and, complementary and coagulation cascades were particularly upregulated in patients with IBS. Cer(d18:1/26:1(17Z)) and PI(14:0/22:1(11Z)) lipids were elevated in FD and FD-IBS but were depleted in ...
Figure 9. Complete metabolism cycle of arginine and proline. Figure 10 shows the biosynthesis of arginine in two different yeasts, Candida and Sacchromyces. The enzymes that play a role in the metabolic pathway are the arginases that are denoted as Arg 2 through 8 in the figure. Sign in ...
J Exp Clin Cancer Res (2023) 42:73 https://doi.org/10.1186/s13046-023-02623-2 Journal of Experimental & Clinical Cancer Research RESEARCH Open Access Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous ...
This was measured in humans, representing 13% of glutamine taken up by the intestine.13 Arginine, and possibly other amino acids such as proline or ornithine, also contribute to the intestinal production of citrulline.17 However, the exact quantitative contribution in vivo of all these potential ...
Interestingly, using KEGG-User Data Mapping (Fig. 2A), four genes were shown to be involved in "histidine metabolism", which includes the amino acid synthesis pathway from histidine to glutamate, and seven genes were shown to be involved in "arginine and proline metabolism", an arginine ...
This enzyme participates in arginine and proline metabolism. This enzyme is widely expressed in bacteria, including streptococcus and actinomyces. The bacterial arginine deiminase expression could be regulated by various environmental factors. This product with the indicated enzyme activity was briefly ...
Research suggests that L-Arginine supplementation may also have a positive effect on aerobic and anaerobic exercise performance. L(+)-Arginine 74-79-3 You may like Metabolism and Antidepressant properties of DL-Phenylalanine May 21, 2025 What are the side effects of L-Proline and its related ...
Arginine can serve many bacteria as a source of carbon, energy, and nitrogen, as a building unit of proteins, and as a precursor of polyamine synthesis14, 27. It can also be an ammonia source for bacterial adaptation to acid environments13, 59, 101. All