The term “administer” or “administering” means to introduce a formulation of the present invention into the body of a patient in need thereof to treat a disease or condition. The term “patient” means a mammal that is treated for a disease or condition. Patients are of, but not limite...
Formulations are developed in order to support the successful delivery of therapeutic proteins. Problems frequently encountered in the context of therapeutic proteins are e.g. poor stability of the protein (storage in refrigerator or freezer is often necessary), poor bioavailability, and patient unfriend...
Any other therapeutically efficacious route of administration can be used, for example absorption through epithelial or endothelial tissues or by gene therapy wherein a DNA molecule encoding the active agent is administered to the patient (e.g. via a vector), which causes the active agent to be ...
Innis, M. et al. “Procedures for Expression, Modification, and Analysis of Human Fibroblast Interferon (IFN-β) Genes in Heterologous Cells” Methods in Enzymology, 1986, pp. 397-403, vol. 119. Kagawa, Y. et al. “Comparative Study of the Asparagine-Linked Sugar Chains of Natural Human ...