2006. Genes are not our destiny: The somatic epitype bridges between the genotype and the phenotype. Nat Rev Neurosci 7:10.1038/nrn2022-c1.Lahiri DK, and Maloney B (2006) Genes are not our destiny: the somatic
However, strengthening the connection between genotype and phenotype is a major challenge facing by plant molecular breeders (Pauli et al. 2016). The advances in next-generation DNA sequencing (NGS) have made identification of QTL/genes associated with complex agronomic traits possible. Genome-wide a...
Copine proteins are highly conserved and ubiquitously found in eukaryotes, and their indispensable roles in different species were proposed. However, their exact function remains unclear. The phytohormone brassinosteroids (BRs) play vital roles in plant
Overexpression of MYB62 resulted in a characteristic gibberellic acid (GA)-deficient phenotype that could be partially reversed by exogenous application of GA. In addition, the expression of SOC1 and SUPERMAN, molecular regulators of flowering, was suppressed in the MYB62 overexpressing plants. ...
Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess. J Clin Endocrinol Metab. 1998;83(7):2244–54. Del Gobbo GF, Price EM, Hanna CW, Robinson WP. No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methyla...
They are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton, which in muscle forms a highly complex network of inter-myofibril connections as well as connections between myofibrils and the sarcolemma [1, 2] and the sarcoplasmic reticulum [2...
Lanes 2 and 6, CC genotype. Lane 3, CS genotype. Table 2. Distribution of PON1 and PON2 Genotype and Allele Frequencies in Cases and Controls Empty CellControls (n= 190)Cases (n= 157) PON1: Genotype: AAa 91 (47.9%) 42 (26.8%) ABb 76 (40.0%) 85 (54.1%)...
Given the influence of early life environmental conditions on gene expression, it is of interest to investigate how the long-term effects of early life trauma are influenced by the individual's genotype. In this view, the long-term effects of maternal separation may differ between different ...
Skewing and waving, thought to be gravity dependent phenomena, occur in spaceflight plants. In the presence of an orienting light source, phenotypic trends in skewing are gravity independent, and the general patterns of directional root growth typified by a given genotype in unit gravity are recapit...
We then discuss the health benefits and detrimental consequences that the interactions between dietary and microbial factors elicit in the host. Finally, we present the promises and challenges that arise when seeking to incorporate microbiome data in dietary planning and portray the anticipated revolution...