it has been shown by comparing the values of correlation coefficients ( r ) of equations describing mechanisms for various reaction systems that, in the reactions of oxiranes with proton donors (carboxylic acids and phenols), the catalytic activity of tertiary amines/pyridines is determined by their...
Amine is a type of compound that is derived from ammonia. In other words, amines are basically classified as functional groups or organic nitrogen compounds.
The present invention is directed to tertiary carbinamine compounds having substituted heterocycles, which are inhibitors of the beta-secretase enzyme, and are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direc...
Metal-free,Visible-light induced Cross Dehydrogenative Coupling of Tertiary Amines with Diazo Compounds:A New Approach to β-Animo α-Diazo carbonyl compounds Nucleophilic addition of diazo compounds to imines is an important method for the synthesis ofβ-animoα-diazo carbonyl compounds via C-C bond...
Romania, it is a teaching university hospital and a tertiary referral center for acute poisoning, and therefore it could be used as a representative institution in this region. Another limitation was that the CBC-based parameters were analyzed only at the time of the patients' presentation and ...
Second, initiation and propagation of electrical signalling by voltage-gated ion channels with the key words calcium antagonists, dihydropyridines, benzodiazepines, phenylalkylamines and the corresponding drugs, in particular nitrendipine and its derivatives, amlodipine, and verapamil. Third, angiotensin I ...
Suitable bases are both organic and inorganic bases, e.g. tertiary amines such as trialkylamines (trimethylamine, triethylamine, tripropylamine, diisopropylethylamine etc.), pyridine and pyridine bases (4-dimethylaminopyridine, 4-pyrrolidylaminopyridine etc.), N-methylpyrrolidone etc., as well as ox...
Particular examples of weakly coordinating solvents that can be used in the present invention include C6˜22 primary alkyl amines, C6˜22 secondary alkyl amines, C6˜22 tertiary alkyl amines, C6˜22 nitrogen-containing heterocyclic compounds, C6˜22 sulfur-containing heterocyclic compounds, C6...
Example compounds of type I are prepared from R3-substituted 2,4-dichloropyrimidines A-1 by nucleophilic aromatic substitution using one or more amines RyNH2 and RzNH2. The order of substitution depends to a great extent on the amines used, the reaction conditions (acidic or basic reaction cond...
example also employ corresponding amounts of sodium alcoholate obtained from the mixture of the cocoaoil fatty alcohols or of the sperm oil fatty alcohols as initial material; the sulfonation may be performed inter alia also by means of addition-products of SO3 on tertiary bases such as ...