Inside the center or nucleus of a cell, our genes are located on twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divideLJ Siegel...
HOW DO TELOMERES AFFECT AGING? Telomeres naturally shorten as you age. This is because telomeres get shorter every time a cell divides. Once a cell gets to the point when its telomeres get so short and can no longer divide, it stops replicating altogether and enters into a state called sene...
Mutations in telomerase components lead to telomere shortening and progressive bone marrow failure in the premature aging syndrome dyskeratosis congenita. Short telomeres are also acquired with aging, yet the role that they play in mediating age-related disease is not fully known. We generated wild-...
Telomeres can be used as a sign of aging;the longer they are, the better. "We know that having shorter telomeres can lead to a shorter life and a greater risk of cancer, heart disease and other diseases, " said researcher Immaculata De Vivo, a professor of medicine at Bri...
The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10−7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10−8) and BRCA1 mutation carrier (P = 1.1 × 10−5) breast cancers and altered promoter assay signal. The minor ...
What is the definition of "telomeres" and what do they not contain? What are the causes of old age? Provide some insight relative to cells and cell function as it relates to aging. What is meant by a control group? Explain in detail. ...
Folic acid (FA) may contribute to improved cognitive function and reduced brain cell damage in the aging brain; furthermore, FA supplementation might inhibit the programmed cell death of neural stem cells (NSCs). However, the mechanism through which this factor influences the reduction of telomeres...
In these more primitive species, it appears that these genes direct longevity, at least in some significant part, by silencing telomeres and sub-telomeric regions, silent mating type loci, and, crucially, the rDNA, suppressing formation of rDNA circles [12, 15]. In contrast, mammalian sirtuin...
Furthermore, low levels of LARP3 promote hTR maturation, increase telomerase activity, and elongate telomeres. LARP7 and MePCE depletion inhibits the conversion of the 3′-extended short (exS) form into mature hTR and the cytoplasmic accumulation of hTR, resulting in telomere shortening. Taken ...
The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10−7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10−8) and BRCA1 mutation carrier (P = 1.1 × 10−5) breast cancers and altered promoter assay signal. The minor ...