For instance, some very powerful drugs usedin chemotherapy and radiationtherapy do kill different types of cancer cells – but they also destroy normal tissue at the same time and are incredibly toxic for the body. Consumption of fruits and vegetables is much subtler and clearly does not affect...
To control variation due to the random partitioning of training and test sets, we repeated this approach with different seeds, resulting in similar AUC values. Models trained with increasing numbers of datasets were generated and evaluated until the best combination was found (see, for example, ...
osteocyt thus substantially advances the modeling of cortical bone version to exogenous mechanical loading.Squamous differentiation of prostate cancer, which makes up about less than 1% of all of the instances, is normally associated with androgen deprivation treatment (ADT) or radiotherapy. This entity...
etc. leads to cancers; third, activation of NF-κB and STAT3 leads to cancer cell proliferation, survival, invasion, angiogenesis and metastasis; fourth, activation of NF-κB and STAT3 leads to resistance to chemotherapy and radiation, and hypoxia and acidic conditions activate these transcription f...
microvesicles have emerged as a challenge in the treatment of prostate cancer (PCa), encountered either when the number of vesicles increases or when the vesicles move into circulation, potentially with an ability to induce drug resistance, angiogenesis, and metastasis. Notably, the exosomal cargo ca...
The relation between cancer cells and their TME is quite similar to the “seeds and soil” relationship, which explains the tactical role of the TME in cancer evolution and progression as a result of the stimulatory or inhibitory signals that the TME provides [28]. The TME includes the ...