The atherosclerotic plaque formation is believed to represent inflammatory response involving enzymatic processes co-factored by trace elements. The possible relation between trace elements and coronary artery disease location was the subject of the study. There were 175 patients (107 (61) men and 68 ...
This disparate location of these two important modes of plaque growth suggests that cell proliferation and collagen gene expression may be under separate biological controls during the development and evolution of human atherosclerosis. 展开 关键词: Cell proliferation Proliferating cell nuclear antigen ...
Resveratrol and sirtuins may have neuroprotective effects through several mechanisms, including reduction of inflammation, inhibition of plaque formation and activation of CREB-regulated transcription co-activator 1 (TORC1) signalling. Some recent studies suggest that the beneficial effects of resveratrol and...
Neuroinflammation and synapse phagocytosis by activated microglia are evident, yet their plaque clearance efficacy is compromised.Levodopa-induced dyskinesia, a motor complication, is a common occurrence in Parkinson's disease patients. The association of genes in the levodopa metabolic process, specifically...
The neovascularization in the plaque eventually contribute to the instability of the plaque, leading to intraplaque hemorrhage, plaque rupture and clinical events6,7. It’s widely recognized that vascular inflammation is closely linked to neovascularization, which are two interplaying key factors ...
calcification factorscarotid plaquematrix metalloproteinasesvulnerabilityThe rupture of atherosclerotic plaque provokes the majority of acute cerebrovascular events. Studies have demonstrated that various matrix metalloproteinases (MMPs) may promote atherosclerotic plaque progression and rupture. However, results have ...
cause discrete changes within the brain tissue. Neurocysticercosis, for example, is the most common cause of epilepsyin the developing world; the parasite causes small calcifications that are scattered throughout the brain. Infections may also form abscesses within the brain that can lead to ...
Objective: Recently we can distinguish unstable coronary plaque from stable plaque with some image modalities such as intravascular ultrasound, CT and MRI, but cannot with blood biomarker. An inflammatory cytokine: Osteopontin (OPN) exist in the aorta, the carotid and the coronary plaque, ...
Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with events. In animal studies, however, high OPG levels result...
The interspecies interactions between periodontal pathobionts and commensals establish a complex metabolic network, a possible precursor to dysbiotic plaque formation. Subgingival microbiota, exhibiting dysbiosis, engage in metabolic processes that disrupt the equilibrium of the host-microbe system. This study...