Without the acidic hydrogen atoms it is not clear what forces would hold the structure together, especially as the negatively charged phosphates near the axis will repel each other. 我们相信给X-射线图的材料是盐,不是自由酸。 没有酸性氢原子它不是确切什么力量将结合在一起使结构,特别是因为消极地...
Theoretical calculation and understanding the mechanism of biomimetic apatite formation in SBF on the surfaces of bioactive coatings In order to understand the formation of various calcium phosphates (CaPs) thoroughly, theoretical calculations were conducted by many researchers. In the previous results, ...
5. PARPs inhibitors Poly ADP ribose polymerases (PARPs) are a family of 17 proteins pooled together based on their structural similarity, specifically, they are composed by two ribose moieties and two phosphates per polymer unit [88]. Known since 1963, these enzymes function is to catalyses ...
Insights into the activation mechanism of class i HDAC complexes by inositol phosphates Nat. Commun. (2016), 10.1038/ncomms11262 Google Scholar 24 R.W. Newberry, R.T. Raines The n→π∗ Interaction Acc. Chem. Res., 50 (2017), pp. 1838-1846 CrossrefView in ScopusGoogle Scholar 25 M...
The first 42 N-terminal disordered amino acid residues of APE1 are highly enriched in positively charged basic lysine and arginine residues, which can engage in electrostatic interactions with DNA phosphates. Recently, Tell and coworkers demonstrated that the first 33 amino acid residues mediate the...
The development of mRNA therapeutics faces the same challenge as any nucleic acid, namely the issue of delivery. As a negatively charged, high molecular weight molecule, mRNA is intrinsically unsuited to cross cellular membranes and to reach its target location, the cellular cytosol. The difficulties...
Ionic compounds are chemical compounds that are connected by electrical charges of individually-charged ion atoms. These compounds...
aWe believe that the material which gives the X-ray diagrams is the salt, not the free acid. Without the acidic hydrogen atoms it is not clear what forces would hold the structure together, especially as the negatively charged phosphates near the axis will repel each other. 我们相信给X-射线...
5. PARPs inhibitors Poly ADP ribose polymerases (PARPs) are a family of 17 proteins pooled together based on their structural similarity, specifically, they are composed by two ribose moieties and two phosphates per polymer unit [88]. Known since 1963, these enzymes function is to catalyses ...
Cloning and characterization of the Arabidopsis cyclic phosphodiesterase which hydrolyzes ADP-ribose 1′′,2′′-cyclic phosphate and nucleoside 2′,3′-cyclic phosphates J. Biol. Chem., 272 (1997), pp. 13211-13219 View PDFView articleView in ScopusGoogle Scholar Gong et al., 2021 Q. Gong,...