PrEP Prevents HIV -- So Where Are the Prescriptions for Women, Sex Workers and Drug Users?Heather Boerner
These use of HIV preventative technolo- gies such as pre- and post-exposure prophylaxis (PrEP and PEP) among the male sex worker community require to be explored in the context of male sex worker's sexual practices and on its own distinct implications in the world of sex work. Access to...
aureus, Gut, Enteric carriage, Bacteremia, Barrier, Virulence Background Staphylococcus aureus is an omnipresent member of the human microbiome that is infamous for causing a broad range of potentially life-threatening infections and for its high capacity to acquire multi-drug resistance [40, 64, ...
Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are
observed downstream of P39 (Fig. 6E) due to the structural restric- tion caused by the presence of Pro at the P39 position of the hexapep- tide complex. Discussion The series of peptide-complex structures presented here provide insights into the catalytic mechanism of DAP BII, which may be ...
TW:In the document, you also write about islatravir as both the treatment for HIV, and as a potential forPrEP. Can you talk a little bit about that drug? Just kind of explain what it is, how it could be used both for treatment and for PrEP?
Furthermore, the human Hsp60 peptide DiaPep277 is in a clinical trial for diabetes (Huurman et al. 2008). The wide-ranging biological actions of cell surface molecular chaperones, which are independent of PAMP contamination, plus the evidence for immunosuppressive/anti-inflammatory actions of the ...
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We identified that the EloB C-terminus, which is not necessary for EloC binding and for E4orf6-mediated depletion of P53, may play a role in improving Vif function. Therefore, the EloB C-terminal tail may be investigated as a promising drug target. Moreover, we found that over-...
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