These analogues are freely water soluble, stable at physiological pH, and stabilize the human topoisomerase I-DNA covalent binary complex with the same sequence selectivity as camptothecin itself. All four compounds inhibited the growth of yeast expressing human topoisomerase I in an enzyme-dependent ...
Date Jan. 20, 1994Sparingly water-soluble active compounds, for example medicinal substances, are converted into the dissolved (molecularly disperse) state by dissolving them in a hydrophilic peptide having a molecular weight above 100 D, for example gelatin. The solubility both during storage and ...
Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited. To discover senolytic targets, we performed RNAi screens ...
Analysis of forage quality related traits: water soluble carbohydrate (WSC), in vitro digestibility of organic matter (IVDOM), neutral detergent fiber (DNF), and digestibility of neutral detergent fiber (DNDF) have previously been reported [36]. In our study, four biomass yield-related traits ...
Compounds accumulating in the media would therefore originate from the myotubes. Lipidomic profiling confirmed that the conditioned media was exogenous palmitate-free (Supplementary Fig. 1b). This conditioned media was transferred to naive differentiated C2C12 myotubes (Fig. 1a). Conditioned media from ...
Acidic heavy Potassium chromate, with a chemical formula of K2Cr2O7, is an important inorganic chemical substance. It is a deep red solid powder that is soluble in water and ethanol, but insoluble in organic solvents such as ether and benzene. This article will provide a detailed introduction to...
Classify the bond in CS2 as ionic or covalent. What is the difference between an ionic and covalent compound bond? What pair of atoms makes a non-polar covalent bond? a. Na and F b. B and F c. P and H d. N and O Which types of covalent compounds are soluble in water, and why...
The levels of chlorophyll A, B, and total chlorophyll were determined in ethanolic extracts during water deprivation by spectrophotometry at 645 nm and 663 nm. Total chlorophyll was expressed as µg/mg of tissue. (B) TBA-reactive compounds. In several stresses, plant cells produce ROS. ...
The amount and composition of root exudates—low-molecular-weight carbon compounds released from living plant roots into soil—are expected to shift under global change, and a growing body of work indicates that root exudates have important impacts on stable soil organic matter dynamics. However, mo...
Water-soluble or water-dispersible polymers comprising alkoxylated diallylamine derivatives, ethylenically unsaturated mono- or dicarboxylic acids, the anhydrides thereof or mixture