Lipid nanoparticlesPhysicochemical propertiesAdsorption-transportation-distribution-clearance processBio-nano interactionsToxic mechanismLNPs' physicochemical properties affect the adsorption-transportation-distribution.LNPs' physicochemical properties affect the bio-nano interactions.Main biotoxicity induced by LNPs are ...
Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA. Mol Therapy-Nucleic Acids. 2012;1: e37. Article Google Scholar Liu D, et al. Microfluidic-assisted fabrication of carriers for controlled drug delivery. Lab Chip. 2017;17(11):1856–83. ...
29,30,31,32,33 Importantly, immunization with chemically modified mRNA encapsulated within a lipid nanoparticle was found to be safe and immunogenic in humans following a Phase 1 clinical trial using an mRNA vaccine targeting H10N8 influenza.34,35 Here we evaluated LNP-encapsulated chemically ...
Current evidence shows that neither ZnO nor TiO2 nanoparticles will cause any harm when they are used in sunscreens. Avoiding suncreams (sunburn and skin cancers) is riskier than nanoparticles. Conclusion The current scientific consensus on the safety of many of these chemicals is safe to use. Ho...
and increasing the levels of cyclin-dependent kinase inhibitors when delivered embedded in lipid nanoparticles at the concentration of 13 ± 5 µg/ml [189]. These nanocapsules induce a halt in the cell cycle resulting in a significant increase in the expression of the P21 gene and a dec...
While designing NPs to facilitate clearance would help reduce their toxicity, a quick clearance would further impair their therapeutic efficacy and targeting. Thus, it is evident that striking a balance is necessary to create safe, effective, and translatable nanomedicines. The hepatic and renal system...
mRNAmRNA encoding the antigen of interest packaged in lipid or other nanoparticles enters cytoplasm and uses cell machinery to transcribe and express the protein leading to an immune response Relatively easy and rapid to make and scale up Highly immunogenic (both antibodies and T cells)Robust innate...
Bioavailability, Biopersistence, Bioprocessing, Biomodification, and Bioclearance (of nanoparticles) ABB: Air-Blood-Barrier AM: Alveolar Macrophages AuNP: Gold NanoParticle BAL: BronchoAlveolar Lavage BALT: Bronchus-Associated Lymphoid Tissue BaP: Benzo-a-Pyrene BMD: BenchMark Dose BSA: Bovin...
(TPGS) is a non-ionic surfactant that forms stable micelles at concentrations of greater than 0.02% w/w48. TPGS is considered a safe pharmaceutic adjuvant by the FDA, which coupled with the observation that this agent can inhibit P-glycoprotein activity49has led to the widespread use of this...
HPV vaccines are administered via IM injections, similar to many other vaccines. They are relatively easy to apply, create a reservoir of immunogenic substances, and have been shown to be sufficiently safe [7]. However, the demand for more convenient routes remains undeniable. ...