Toxicological profile of lipid-based nanostructures: are they considered as completely safe nanocarriers?Nanotechnologylipid-based nanomaterialsgenotoxicityepigenicitycytotoxicitynanomaterials exposure routsNanoparticles are ubiquitous in the environment and are widely used in medical science (e.g. bioimaging, ...
Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA. Mol Therapy-Nucleic Acids. 2012;1: e37. Article Google Scholar Liu D, et al. Microfluidic-assisted fabrication of carriers for controlled drug delivery. Lab Chip. 2017;17(11):1856–83. ...
Steering the course of CAR T cell therapy with lipid nanoparticles Muhammad Babar Khawar Ali Afzal Haibo Sun Journal of Nanobiotechnology (2024) Changes in the innate immune response to SARS-CoV-2 with advancing age in humans Sudhanshu Agrawal Michelle Thu Tran Anshu Agrawal Immunity & Age...
Nrf2 signaling cascade through controlling the interaction between Nrf2 and Keap1 [6,115]. These nature-derived molecules are believed to provide a rather safe method of anticancer interventions compared to their synthetic counterparts, leading to a new horizon of chemoprevention and therapeutics. Some ...
While designing NPs to facilitate clearance would help reduce their toxicity, a quick clearance would further impair their therapeutic efficacy and targeting. Thus, it is evident that striking a balance is necessary to create safe, effective, and translatable nanomedicines. The hepatic and renal system...
In February 2021, “shaming” articles appeared, calling people like Dr. Joseph Mercola “quacks” forexpressing concernover the lipid nanoparticles in these jabs. Mercola simply stated the truth: the lipid nanoparticle delivery systemhad never been approvedfor use in a vaccine or drug yet was bei...
The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo-the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable...
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrie
recently described lipid nanoparticles that selectively target B cells in the spleen [84]. Nonetheless, efficient mRNA expression in most cell types does require the mRNA to be encapsulated into nanoparticulate delivery vehicles that aid cellular uptake and mediate mRNA escape from endosomes to cytosol...
Numerous delivery approaches allow the translocation of active proteins, including viral and nonviral carriers, nanoparticles, and lipid-based particles3. Systems that are able to deliver cytosolic protein would offer new approaches for combatting a variety of diseases, including cancer4, diabetes5, ...