ribonucleotide may affect OCT4 condensation, as RNA interaction with IDR protein can modify LLPS distribution19,24,37. Consistently, treatment with the 1, 6-HD, which is supposed to disrupt weak hydrophobic interactions observed in phase-separated granules23, diminished OCT4 condensates and AR or ...
appearance of polymer鈥搒urfactant hybrid micelles.Analysis of the interaction shows a strong and nonspecific reactionbetween the polymers and the anionic surfactant sodium dodecyl sulfateand weak but polymer-state-sensitive interactions between the polymerand the cationic surfactant hexadecyltrimethylammonium ...
A. Van der Waals forces and hydrogen bonds are both weak chemical interactions. B. Weak bonds are constantly made and broken at physiological temperature. C. Hydrophobic interactions stabilize macromolecules. D. Covalent bonds are the important forces for protein-protein interaction.如何...
Rechargeable LiBs are a critical component of sustainable energy infrastructure13,14, and demand for use in electric cars and electronics (e.g., cell phones, medical devices, smart watches, laptops) is anticipated to grow exponentially over the next decade15. Up to 96% of bis-FMeSI is recove...
Weak protein–protein interactions in live cells are quantified by cell-volume modulation. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.1700818114 (2017). Sukenik, S., Salam, M., Wang, Y. & Gruebele, M. In-cell titration of small solutes controls protein stability and ...
3.6. Non covalent interactions - reduced density gradient analysis Recently, it has been realized that NCI-RDG investigation was able to distinguish the weak interactions better than any other analysis. utilizing Non-covalent index (NCI) method we have analysed non-covalent interactions like van der...
Because of auxin-dependent physical and functional interactions between TMKs and the putative ABPs ABL1/2, we hypothesize that ABLs and TMKs form auxin receptor complexes on the cell surface. To test this hypothesis, we first determined whether ABL1 indeed directly binds auxin as predicted (Figu...
may lead to intra-molecular misfolding and the gradual formation of increasingly stable inter-molecular ensembles called aggregates or amyloids. Likely owing to wrong hydrophobic interactions, the earliest forms of misfolded and aggregated species can compromise the integrity of cellular membranes and the...
The formation of protein condensates is mediated by weak, multivalent interactions, commonly requiring low complexity or intrinsically disordered regions28,37. SMART sequence analysis38 identified regions of low complexity (aa 388–400 and 404–417) within the intrinsically disordered C-terminal tail of...
(a) Binding of Bet v 1a (10 μ M) to immobilized cathepsin S was weak at near neutral pH values (8.5, 7.4 and 6.7). Only at acidic pH (pH ≤ 5.5) binding affinity increased significantly. (b) By contrast, binding affinity of Bet v 1d (10 μ M) to cathepsin S ...