The Hematology/Oncology (Hem/Onc) Central-line Associated Bloodstream Infection (CLABSI) Rates Are Impacted by the 2013 National Health Safety Network (NHSN) DefinitionsIssue Discussions regarding CLABSI rates in the Heme/Onc population suggest that many CLABSIs may be due to translocation of ...
Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a rare, aggressive subtype of non-Hodgkin lymphoma and has a complex inflammatory microenvironment. Although most patients can be cured with standard-of-care immunochemotherapy, patients who h
Journal of Hematology & Oncology volume 12, Article number: 2 (2019) Cite this article 6022 Accesses 93 Citations 1 Altmetric Metrics details Abstract Background Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived...
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to conventional small molecule inhibitors (SMIs) because of their unique mechanism of action (MOA, i....
Cancer immunotherapy has already entered the mainstream of oncology [23]. Existing strategies focus on enhancing immune destruction of cancer cells by a variety of means (Table 1). One of the most successful and longstanding forms of cell-based immunotherapy is allogeneic stem cell transplant for ...
Chromosomes are thread-like structures in which DNA is tightly packaged within the nucleus. DNA is coiled around proteins called histones, which provide the structural support. Chromosomes help ensure that DNA is replicated and distributed appropriately during cell division. Each chromosome has a ...
By using straightforward statistical reasoning and examples from the oncology literature, we will argue that OS should no longer be the primary end point of most future cancer clinical trials. Although the focus of our reasoning will be pivotal phase III trials that aim at regulatory approval, ...
and findings she is most looking forward to at this year’s event. She speaks withRobert Figlin, MD, the Steven Spielberg Family Chair in hematology-oncology at Cedars-Sinai Cancer Center in Los Angeles, about steps being taken to ensure that key information from the co...
(ICD-10), the mammoth set of code changes required by the Centers for Medicare & Medicaid Services (CMS), has involved a huge commitment to staff training and also much attention to the finer details, says Kathy Oubre, chief operating officer of Pontchartrain Hematology Oncology in Covington, ...
Multiple submicroscopic genetic alterations with prognostic significance have been discovered, including internal tandem duplication of the FLT3 gene, mutations in the NPM1 gene, partial tandem duplication of the MLL gene, high expression of the BAALC gene, and mutations in the CEBPA gene. Application...