Sphingosine-1-phosphate levels are inversely associated with left ventricular and atrial chamber volume and cardiac mass in men: The Study of Health in Pomerania (SHIP)doi:10.1007/s00392-023-02200-9Schielke, JanIttermann, TillGro, Stefan
Here, we report the binary interaction between PAX8 and the products of theMECOM(MDS1–EVI1 complex locus) locus and dissect its function.MECOMis a transcriptional unit originally constituted by two main promoters (separated by 500 kb) driving the expression of the MDS1 and EVI1 proteins. ...
Calcium (Ca2+) is a universal regulatory element that intimately couples primary biotic and abiotic signals to many cellular processes, allowing plants and animals to develop and adapt to environmental stimuli1,2. Each Ca2+response can be specified by the spatial release of Ca2+in specific cell t...
(PTH) and aldosterone concentrations], and FFA were measured during an euglycemic hyperinsulinemic clamp test in 49 patients with untreated essential hypertension.Serum potassium, phosphate, PTH, and FFA concentrations decreased during hyperinsulinemia, while serum ionized calcium concentration, pH, and PRA...
Such contacts may ensure different functions as, for example, lipid or calcium homeostasis that could be essential for melanosome integrity. Clustered melanocores are not autophagosomes and acidic organelles Clusters of melanosomes have been described in white and Asian skin, but their structural ...
Before the acquisition, cells were washed twice with a modified KRBH buffer (140 mM sodium chloride; 3.6 mM potassium chloride; 0.5 mM sodium phosphate monobasic; 0.5 mM magnesium sulfate; 1.5 mM calcium chloride and 10 mM HEPES; pH = 7.4). The bioenergetic profile of the cells was ...
A role for APP has been suggested in neurite outgrowth and synaptogenesis, protein trafficking along axons, cell adhesion, calcium metabolism, and signal transduction (reviewed in (1, 2)). During its life cycle, APP is cleaved into various fragments mediating different functions. Next to Aβ (...
The duration of a sleep or wake episode is calculated by taking the average of consecutive sleep or wake bouts, which is inversely related to PSW or PWS, respectively. Long-term recording with development lasted approximately 2 months in male mice, from P21 (just after weaning) to P84. ...
Inversely, if the ratio of ASIC2a/ ASIC1a is 2:1, the rate of desensitization is decreased39. We also found that the number of ASIC1a positive cells was decreased and ROD of ASIC1a was increased in adult rats. A possible interpretation to these findings is that the expression of ASIC1a...
Since CFTR-/-mice do not express the cAMP-regulated chloride channel (Snouwert et al., (1992) Science 257:1083-1088), DHA therapy may be activating and/or inducing the expression of other chloride conductance pathways (e.g., calcium-activated chloride conductance) believed to compensate for ...