What type of blood cells are lymphocytes and monocytes? What are blast cells in bone marrow? What organ system produces blood cells? What type of cell makes up the epithelial tissue of the heart? What is the largest cell in the body?
Are all blood cells made in bone marrow? Why do people need bone marrow transplants? Where do doctors take bone marrow from for a transplant? Where are white blood cells made besides in the bone marrow? Are endothelial cells in bone marrow?
The in vivo response was similar in all three treatment arms with a comparable blast decline in the peripheral blood. The percentages of patients with a clear non-response (M3 marrow) and moreover, the level of minimal residual disease (MRD) on Day 15 or at the end of induction were ...
Molecular epidemiology suggests that the risk conferred by gene variants have decreased the expression of specific products, but contribute to the intrinsic vulnerability of immature cells to initiate an abnormal clone. In this context, the polymorphism of NQO1 gene involved in benzene activation and pa...
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist in the blood of mice and humans. Compared wi
(CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and mechanisms of response and toxicity to CICB are needed. To address this, we profiled the blood, tumor and gut ...
Bulk CD28 splice variants were amplified from PHA blast cDNA with recombinant Taq polymerase (Thermo Fisher Scientific) and primers binding to the UTRs, as described in the “mRNA purification, RT-PCR and RT-qPCR” section. PCR products were cloned with the TOPO TA cloning kit (Thermo Fisher...
New blood cells of different cell lineages are formed from bone marrow hematopoietic stem cells (HSCs), which provide a constant supply of blood cells throughout life. HSCs show considerable plasticity and can reprogram their gene expression in response to signals produced by a combination of ...
In healthy somatic cells, cell cycle-associated factors interact with transcription factors such as MyoD (myo- blast determination protein 1), which regulates the expression of muscle-related genes, committing undifferentiated cells to the muscle. Upon cell cycle exit, the transcription factors ...
White blood cells are able to move from blood plasma to surrounding tissues. What is the functional significance of this ability? What is the basal nuclei function? What are the functions of the Leydig cells? What are the functions of cholesterol in the body?