However, the discovery of a single allele proven to be associated with control of blood pressure could lead to the discovery of relevant and novel physiological targets for the prevention and treatment of hypertension.HarrapStephenBEBSCO_bspLancet...
However, these roles have not been validated in vivo yet. In this work, we analyze mice with SOXC loss or gain of function in osteogenic cells to test if and how SOXC control adult bone mass accrual and maintenance. We show that the three genes promote cortical bone thickening and ...
On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both...
the trinucleotide context of theKRASmutation and the relative activity of the mutational signature in that tumor were used to calculate the probability that the allele in an individual tumor was caused by any detectable
Oncogenes and tumor suppressor genes are clustered around recombination hot spots or fragile sites in the genome, because double-strand break is the common initial step in translocation, deletion and gene amplification. FGFR2 gene on human chromosome 10q26 is amplified in diffuse-type gastric cancer...
Recessive resistance to Bean common mosaic virus (BCMV) in common bean (Phaseolus vulgaris L.) is conferred by six alleles: bc-u, bc-1, bc-12, bc-2, bc-22, and bc-3 (1). The bc-3 allele functions as mutated eIF4E translation initiation f... X Feng,GE Orellana,JR Myers - 《...
What are genes, chromosomes, and alleles? What are the potential offspring from a mating between two heterozygous individuals? What type of allele is always expressed regardless of whether the individual is homozygous or heterozygous for it? A. Both the domi...
Furthermore, several pathways, including those of starch and sucrose metabolism, are enriched for strong signals of adaptations to a diet rich in roots and tubers, whereas signals associated with polar ecoregions are overrepresented in genes associated with energy metabolism pathways. 展开 ...
1g,h). Collectively, these data indicate that formaldehyde-induced DPCs are exclusively eliminated from active genes associated with RNAPII transcription activity. Fig. 1: Formaldehyde-induced DPCs are removed from active genes. a, Schematic representation of the experimental procedure for DPC-seq in ...
in total. Through integrating genomic fine-mapping with brain expression and chromosome conformation data, we identify candidate causal genes within 33 loci. We also show for the first time that the common variant association signal is highly enriched among genes that are under strong selective ...