Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment outcome. This study dissects the intra-tumoral diversity of CAFs in basal cell carcinoma, squamous cell carcinoma, and melanoma using molecular and spatial single-cell analysis. We identify three distinct CAF su...
How can you tell if a pigmented legion is actually a mole, and not a freckle or skin tag? When is a mole potentially cancerous? Does your mole ‘profile’ make you prone to melanomas? "It is important to monitor your moles throughout the year," Dr Derrick Phillips, a London-based...
Atypical moles are another type of precancerous lesion. These moles may have uneven borders, and often grow rapidly. They may be asymmetrical in shape, and they are usually multi-colored. These moles are believed capable of developing into malignant melanoma. Most dermatologists remove them for ...
The immediate goal is to create vaccines that destroy cancer cells—but some scientists are also testing vaccines that might prevent someone from developing cancer.
Innate immunity is the first line of the host immune system to fight against infections. Natural killer cells are the innate immunity lymphocytes responsible for fighting against virus-infected and cancerous cells. They have various mechanisms to suppres
Squamous cell carcinoma of the skin and melanoma are the rare progeny of precancerous lesions that usually remain stable or regress. For SCC the sequence appears to include TP53 mutant clones in normal skin; dysplasia; carcinoma in situ; and SCC. When such lesions are contiguous, their TP53 ...
Acral lentiginous melanoma, which occurs on the palms of hands, under nails, on the soles of feet, and on moist surfaces that line body cavities. What Are the Types of Precancerous Skin Neoplasms? Precancerous growths.Precancerous skin growths, also called actinic keratosis orsolar keratosi...
ovarian cancer and non-small cell lung cancer. It will release results from its own phase 2 melanoma trial (of 131 patients) using immunotherapy and an mRNA vaccine combination later this year. Its primaryaimis to measure cancer progression and survival over 24 months in previously untreated pati...
There are many strengths and limitations to all of the physical, chemical, and biological approaches to cancer treatment that have been developed to date, with immunotherapy recently emerging as a robust option for the systemic treatment of many malignancies. Engineering-based strategies such as those...
Normally, cell growth, cell division and cell death are tightly regulated processes. But mutations in a cell's DNA can disrupt this regulation, leading to abnormal cell proliferation, forming tumors. Tumors can be benign (non-cancerous) or malignant (cancerous). Malignant tumors are dangerous be...