Connexins form gap junction channels that provide a hydrophilic path between cellinteriors. Some connexins, particularly the lens connexins, cx46 and cx50Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes.These hemichannels are a non-selective conduit to...
The importance of connexins (Cxs) in the cochlear functions has been indicated by the finding that mutations in connexin genes cause a large proportion of sensorineural deafness cases. However, functional roles of connexins in the cochlea are still unclear. In this study, we compared the relative...
Presents a study that explored the role of oligodendrocyte connexins in normal myelination in the central nervous system. Procedures used in investigating the unaffection of central myelination with regard to mutations in Cx32, a gap-junction channel-forming protein; Assessment of the reaction of ...
and plays a vital role in controlling the astrocyte inflammatory response. Interestingly, pathways related to mitosis and cell cycle checkpoints were also enhanced in WT-stimulated cells (Supplementary Tables1and2). This trend, which also occurs in reactive astrocytes35, is in line with evidence im...
structure and functions of gap junctions and their constituent connexins in the mamma1ian cns Numerous data obtained in the last 20 years indicate that all parts of the mature central nervous system, from the retina and olfactory bulb to the spinal ... EY Kirichenkoa,*,SN Skatchkovb,......
Connexin 43 (Cx43), which is expressed in virtually all types of bone cells, is the major component of gap junctions and plays important roles in signal transduction. Previous studies have revealed that the dynamic balance of bone mass was broken by reduced Cx43 expression rates in the ...
The GJB2 gene encoding the gap junction protein 2, also called Connexin 26, is one of a growing number of genes found to have mutations which can result in hearing loss. One particular GJB2 mutation, 35delG accounts for 50-80% of recessive deafness in the Caucasian population of European...
We aimed to explore whether specific high-sucrose intake in older female rats affects myocardial electrical coupling protein, connexin-43 (Cx43), protein kinase C (PKC) signaling, miR-1 and miR-30a expression, and susceptibility of the heart to malignant arrhythmias. Possible benefit of the suppl...
Additionally, the role of microglial in stroke is complex in that microglial activation can result in a range of phenotypes both pro- and anti-inflammatory and phagocyto- sis can attenuate inflammation but also cause more neuronal damage by phagocytosis of viable neurons[65,66]. Therefore, the ...
as P2X7R in immune cells is important in inflammatory processes25,27,41. Additionally, the effect of P2X7R SNPs in glucose homeostasis should be considered. It is not yet clear whether the P2X7R signatures will be the same in human and rodent β-cells, as different isoforms may be directin...