Don Colburn
A literature search was conducted in PubMed using search terms associated with substance use (tobacco, nicotine, smoking, cigarettes, cannabis, marijuana, opiate, opioid, heroin, cocaine, synthetic opioids/cannabinoids, cathinones, LSD, dimethyltryptamine (DMT), 3,4 methylenedioxymethamphetamine (MDMA),...
The immunological synapse is a molecular hub that facilitates the delivery of three activation signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting cells (APC) to T cells. T cells release a fourth class of signaling entities, trans-synaptic vesicles (tSV), to ...
A 300 μl solution of 5% formic acid and 0.2% trifluoroacetic acid (TFA) R2 50 μm Poros (Applied Biosystems) beads slurry in water was added to the gel pieces before returning the samples to the shaker for an additional 3 h at 4 °C. Beads were loaded onto equilibrated C18...
However, it remains to be seen if these new treatments will revolutionize the treatment of TRD. Areas covered: The present review focuses on the efficacy of serotoninergic psychedelics psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), ayahuasca, 5-methoxy-N,N-...
However, not every mutation in a DNA sequence results in changes to the amino acid sequences, and this is one of the disadvantages of using an allozyme as a molecular marker [107]. Other disadvantages include heterozygote deficiencies due to null alleles and the amount and quality of tissue ...
x-G-N-x-M-N (single-letter amino-acid nota- tion; x is any amino acid) motif present in the FH2 domain of most fungal and metazoan formins [10] to search for puta- tive Arabidopsis formin homologs and found eight such inter-related genes (see Materials and methods and Table 1)....
Data are expressed as the mean ± SEM. Columns not sharing superscripts are significantly different, p > 0.05. B. Total polyphenol content measured in gallic acid equivalents per gram of various fruit powders. Acai, acai powder; Blue, blueberry powder; Cran, cranberry powder; Pom, pomegranate ...
Morrison1, Georgina Cano2, Pierfrancesco Chiavetta1 & Domenico Tupone1,3* Within the central neural circuitry for thermoregulation, the balance between excitatory and inhibitory inputs to the dorsomedial hypothalamus (DMH) determines the level of activation of brown adipose tissue (BAT)...
Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use carbonic anhydrase 9 (CA9) antibodies to mark acidic areas in both hypoxic and respiring tumor areas, along with an HRE-GFP re...