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Background Elevated levels of B Lymphocyte Stimulator(BLyS) play an important role in the pathogenesis of Systemic Lupus Erythematosus. Although anti BLyS-targeted therapies have shown promise in the treatment of SLE, results of clinical trials highlight that a number of patients remain unresponsive ...
Moreover, although the proliferation rate was lower, LCs were more powerful stimulators of allogeneic naive CD8+ T-cell proliferation (Figure 2b). Download: Download full-size image Figure 2. Human migratory Langerhans cells show higher allostimulatory function than migratory CD1c+ dermal dendritic ...
Ileal short-circuit current (ΔIsc) upon stimulation with m epithelial stimulator carbachol or n neurostimulator veratridine. Data expressed as mean ± S.E.M. b–d, g–j Color denotes colonization treatment (GF = yellow, B = red, Y = green, BY = royal blue); ...
year PFS and OS rate of 36% and 52%, respectively, and an ORR of 58% [7]. Recently, the association of nivolumab plus relatlimab, a monoclonal antibody targeting LAG-3 [9], has been approved for first-line treatment of unresectable or metastatic melanomas with PD-L1 expression lower ...
Different stimulators of macrophages may cause distinct miRNA expression profiles in various subsets of macrophages. Glioblastoma-infiltrating macrophages, which are activated primarily by M-CSF, display downregulated miR-142-3p com- pared with GM-CSF-treated cells42. Consistent with our findings, miR-...
Furthermore, CLL cells were surprisingly potent stimulators of Th cell proliferation. With the exception of one patient, the Figure 2. Model system to assess the antigen-presentation capacity of CLL cells: HLA-DRB1*0401+ CLL cells are cocultured with a human Th cell clone (T18) that is ...
During aging, neuronal organelles filled with neuromelanin (a dark-brown pigment) and lipid bodies accumulate in the brain, particularly in the substantia nigra, a region targeted in Parkinson’s disease. We have investigated protein and lipid systems in
s, respectively, which are comparable to ranges reported for PM proteins and lipids17,18,19. To analyze tSV from TH cells we used BSLB presenting a range of α-CD3ε Fab densities, and physiological densities of the adhesion molecule ICAM1 (200 molec/µm2) and costimulator receptor ...