The article reports on a population-based longitudinal analysis of data from elderly residents of Alberta, Canada which revealed that the hazard ratios for hyperkalaemia and renal dysfunction associated with angiotensin-converting enzyme (ACE) inhibitor/angiotensin receptor blocker (ARB) combination ...
ACEinhibitortreated上海瑞金医院施仲伟CHARM-Added: Primaryoutcome CVdeathorCHFhospitalisationNumberatriskCandesartan 1276 1176 1063 948457Placebo 1272 1136 1013 9064220123years01020304050PlaceboCandesartan3.5HR0.85(95%CI0.75~0.96),p=0.011 AdjustedHR0.85,p=0.010483(37.9%)538(42.3%)%上海瑞金医院施仲伟Captopril00....
3、对照组 1.01.251.50.750.5727/7489 (9.71%)650/9712(6.69%)192/3046(6.30%)2171/29,022(7.48%)3501/49,214(7.11%)3740/49,269(7.59%)ACEI有利于ACEI有利于对照组Odds reduction ( SD)7 2ACE Inhibitor MI Collaborative Group. Circulation. 1998;97:2202-12.早期干预SMILE试验:ACEI治疗使NSTEMI患者1年...
According to it, use of an ACE inhibitor or an ARB was linked with a greater decrease in glomerular filtration rate (GFR) than were control management strategies. It was also found that utilization of either drug was associated with a greater decline in hematocrit than were control strategies....
ACE Inhibitor Myocardial Infarction Collaborative Group Indications for ACE inhibitors in the early treatment of acute myocardial infarction Systematic overview of individual data from 100000 patients in randomized trials Circulation 1998972202-2212 ISIS-4[45]的亚组分析资料显示 NSTEMI 患者未 ...
40% ACE inhibitor intolerant 上海瑞金医院施仲伟 Number at risk Candesartan 1013 929 831 434 122 Placebo 1015 887 798 427 126 0 1 2 3 years 0 10 20 30 40 50 Placebo Candesartan % HR 0.77 (95% CI 0.67~0.89), p=0.0004 Adjusted HR 0.70, p0.0001 3.5 406 (40.0%) 334 (33.0%) 上海...
These results demonstrate that valsartan is as effective as an ACE inhibitor (pre-specified non-inferiority hypothesis was met) in reducing the risk of mortality in this patient population. It was estimated that valsartan had an effect that was 99.6% that of captopril, supporting the conclusion ...
? Hornig et al concluded that ACE inhibition increases flow-dependent dilation by a mechanism that involves the accumulation of endogenous bradykinin. 对32项ACEI用于有症状心衰患者(NYHA心功能II或IV级)的试验所作的荟萃分析表明,ACEI能显著降低心衰患者的总死亡率达23%,降低死亡率和住院率达35%。同时ACEI...
研究已证实,在衰竭的心脏组织中,ACE m-RNA、ACE的活性和AngⅡ水平均显著增加,而组织中的ACE比循环中的更难抑制,这提示在临床上对组织中ACE的抑制需要更大剂量的ACEI,以减少组织中AngⅡ的含量。大剂量较之小剂量对血流动力学、神经内分泌、症状和预后产生更大作用。赖诺普利治疗和生存评价研究(ATLAS)对3 164例...
发表在《JAMA》的该项研究,旨在确定血管紧张素转换酶(ACE)抑制剂或血管紧张素受体阻滞剂(ARB)是否能改善新冠住院患者的预后。 2021 年3月16日至2022年2月25日,在7个国家的69个研究中心,721名危重症患者和58名非危重症住院成人被随机分配至RAS抑制剂或对照组,最终随访时间为2022年6月1日。