Gastrointestinal (GI) cancers are a major global health burden, representing 20% of all cancer diagnoses and 22.5% of global cancer-related deaths. Their aggressive nature and resistance to treatment pose a significant challenge, with late-stage survival rates below 15% at five years. Therefore, ...
Arachidonic acid(AA) is one of the main omega-6 fatty acids present in food of animal origin. In addition, the body synthesizesAAby transforminglinoleic acidpresent in cereals, nuts, or vegetable oils. AA has been considered as alipidthat activates inflammatory pathways (Bazinet & Laye, 2014)...
Fatty acid structure affects cellular activities through changes in membrane lipid composition and the generation of a diversity of bioactive derivatives. Eicosapolyenoic acids are released into plants upon infection by oomycete pathogens, suggesting they may elicit plant defenses. We exploited transgenic ...
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn ...
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn ...
Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation. Peripheral tissues undergo many forms of diseases that are freq...
Of all the metabolites, AA is an important fatty acid that has anti-diabetic action and hence, normal activity of Δ6 desaturase is needed to maintain normal plasma and tissue levels of AA. Furthermore, AA is the precursor of LXA4, a potent anti-inflammatory molecule. Our recent studies ...
3H), including amino acid biosynthesis; nucleoside and nucleotide biosynthesis; cofactor, cogroup, electron carrier, vitamin biosynthesis; fatty acid and lipid biosynthesis, etc. In conclusion, the intestinal microecological balance of dairy goats is destroyed by HS, and melatonin may reduce the ...
Arachidonic acid (AA) is a polyunsaturated fatty acid that participates in the inflammatory response mainly through bioactive-lipids formation in macrophages and also in the phagocytic NADPH oxidase 2 (NOX2) activation. NOX2 is the enzyme responsible for a huge superoxide formation in macrophages, es...
This might play a role in the anchorage of these cells to host cells during infections. This indicates that 3-OH fatty acid production may be an important virulence factor in C. albicans as well as in C. dubliniensis, since 3,18-diHETE production has also been found in this closely ...