1. 力引导的构象采样 在快速折叠蛋白中(WW Domain蛋白为例),使用CONFDIFF在不同程度的力引导(η)和序列条件(γ)下生成构象结果如图2所示。结果表明,力引导可以在不显著降低多样性的情况下提高构象稳定性。 图2 在不同的力引导(η)和序列条件(γ)下,WW Domain的采样构象的能量(左)和多样性(右) 2. 快速折...
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the...
PD-1)、细胞毒性T淋巴细胞相关抗原4(cytotoxic T lymphocyte antigen 4, CTLA-4)、淋巴细胞活化基因3蛋白(lymphocyte activation gene 3 protein, LAG-3)、T细胞免疫球蛋白粘蛋白分子3(T cell immunoglobulin and mucin domain-contain...
(androgen receptor-interacting protein 4), HSPC325 or SRISNF2L, is a 1,467 amino acid nuclear protein belonging to the SNF2/RAD54 helicase family that consists of one helicase ATP-binding domain and a helicase C-terminal domain. RAD54L2 is a DNA helicase that regulates androgen receptor (...
一、热休克蛋白90(Heat shock protein 90,Hsp90)是真核生物中一种非常重要的蛋白质。研究发现,肿瘤细胞中的Hsp90表达水平会异常升高,并发挥重要作用,主要表现为两个方面:(1)Hsp90会分泌至肿瘤细胞膜表面(extracellular Hsp90, eHsp90),促进肿瘤的迁移、侵袭和转移,并具备介导内吞的作用;(2)Hsp90通过分子伴侣功...
CUB domain containing protein 1 CD319 CRACC, SLAMF7 66kD Ig TM predicted: T, B and DC subset, NK, upregulated in DC regulate T and NK cells CD320 8D6, VLDL CD321 JAM1, F11 receptor, KAR 12.5kD IgSF, Type I, AVS...
Androgen receptor (AR) signaling continues to drive castration-resistant prostate cancer (CRPC) in spite of androgen deprivation therapy (ADT). Constitutively active shorter variants of AR, lacking the ligand binding domain, are frequently expressed in CRPC and have emerged as a potential mechanism ...
This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy...
Protein domain dynamics was analyzed by DynDom40. Structural figures were prepared in UCSF ChimeraX v1.441. Yeast strains, plasmids, and antibodies The detailed information on the yeast strains and plasmids used in this study is listed in Supplementary Table 2. All yeast culture reagents were ...
By developing an aniten based bifunctional degrader (ANITAC for ANITen bAsed Chimera), our goal is to eliminate any forms of AR protein found in castration-resistant prostate cancer (CRPC), that can potentially drive disease progression, including LBD mutants and AR truncated variants.Methods: ...