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Compound 154 also inhibits protein expression of AR and AR splice variants (ARv567es and AR‐V7) without altering AR mRNA levels. Compound 154 binds to AR directly, but not to STAT3 and is identified as an antagonist of the AR amino‐terminal domain (NTD) by disrupting protein‐protein ...
The AR protein has four functional domains (Figure 2). The N-terminal domain (NTD) is the most Cancers 2017, 9, 14 8 of 34 variable and least conserved domain; it is needed to form a transcriptionally active molecule. Precisely, the NTD contains the activation function 1 (AF-1) domain...
To further confirm the relationship between KDM4A-AS1 and AR protein, we performed immunohistochemistry on the same series tissue array to identify AR protein expression in same patients (Fig. 3A). By comparing the staining scores, we found that KDM4A-AS1 showed a high positive correlation with...
The NTD domain accounts for more than half of the entire AR protein as in Fig. 2 (amino acids 1–558). AR NTD contains polyglutamine (ploy-Q) and polyglycine (poly-G) repeats, and the length of these two repeats is highly variable in the human population43,44. The latest human AR ...
[Science] Evolutionary-scale prediction of atomic-level protein structure with a language model.[Paper],[Code] [bioRxiv] Universal cell embeddings: A foundation model for cell biology.[Paper],[Code] [bioRxiv] Large scale foundation model on single-cell transcriptomics.[Paper],[Code] ...
一、热休克蛋白90(Heat shock protein 90,Hsp90)是真核生物中一种非常重要的蛋白质。研究发现,肿瘤细胞中的Hsp90表达水平会异常升高,并发挥重要作用,主要表现为两个方面:(1)Hsp90会分泌至肿瘤细胞膜表面(extracellular Hsp90, eHsp90),促进肿瘤的迁移、侵袭和转移,并具备介导内吞的作用;(2)Hsp90通过分子伴侣功...
Background:The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ...
ELISA Kit for Human PDZ and LIM domain protein 1 0.156-10 ng/mL 大鼠糖缺失性转铁蛋白(CDT)ELISA 人逆转录转座子衍生蛋白PEG10(Retrotransposon-derived protein PEG10)ELISA 0.312-20 ng/mL. 大鼠糖皮质类固醇受体(GR)ELISA ELISA Kit for Human Retrotransposon-derived protein PEG10 0.312-20 ng/mL. ...
and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (...