Blood tests showed negative test results for anti-thyroglobulin, anti-thyroid peroxidase, anti-nuclear and anti-SS-A/ SS-B antibodies. The serum anti-AQP4 antibodies titer was 92048 at both 8 and 15 weeks. The patient was treated with steroid therapy, and her sensory disturbance of the right...
To test whether the NMO- IgG preparations I, III, and IV are also able to initiate astro- cyte destructive lesions in our rat model of experimental NMOSD [24], we injected these NMO-IgGs into Lewis rats after opening the blood-brain barrier of these animals with MBP-specific T cells. ...
aquaporin 4 BBB: blood brain barrier BN rat: Brown Norway rat BCR: B cell receptor CNS: central nervous system CSF: cerebral spinal fluid DC: dendritic cell EAE: experimental allergic encephalomyelitis HLA: human leukocyte antigen IgG: IgM: immunoglobulin G, M Kiv: potassium inwar...
Laboratory tests showed low hemoglobin (112), slightly elevated serum neuron-specific enolase (12), and low levels of vitamin D (17 nmol/L), but the other laboratory findings were normal, including S-100B and the anti-streptolysin O test. Blood and urine tests for acute porphyrias were ...
Here, we aimed to test EPO's effects on blood–brain barrier (BBB) disruption morphologically and functionally following ICH, which has not been well investigated. We also examined whether the effects were dependent on aquaporin-4 (AQP4). We detected the expression of perihematomal AQP4 and ...
Anti-AQP4 (+) patients had a slightly higher number of white blood cells (WBCs) in CSF (11.29 ± 4.27) than anti-AQP4 (-) patients (8.47 ± 2.07). However, the values of IgG index in anti-AQP4 (+) patients were significantly higher than those of anti-AQP4 (-) patients...
The water-selective channel protein aquaporin-4 (AQP4) contributes to the migration and proliferation of gliomas, and to their resistance to therapy. Here we show, in glioma cell cultures, in subcutaneous and orthotopic gliomas in rats, and in glioma tum
New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Aquaporin-4 (AQP4) is the major water channel in the CNS. Its expression at fluid-tissue barriers (blood鈥揵rain and brain鈥揷erebrospinal fluid barriers) ... GT Manley...
Blood samples from the fetal pigs were used for bio- chemical analysis. As references, kidneys from five female and three male postnephrogenesis pigs were performed with the same proce- dure as fetuses. Extraction of Genomic DNA Genomic DNA was extracted from right kidney tissues using lysis ...
Here, we aimed to test EPO's effects on blood–brain barrier (BBB) disruption morphologically and functionally following ICH, which has not been well investigated. We also examined whether the effects were dependent on aquaporin-4 (AQP4). We detected the expression of perihematomal AQP4 and ...